Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

Jane C. Figueiredo, Fred R. Hirsch, Lawrence H. Kushi, Wendy N. Nembhard, James M. Crawford, Nicholas Mantis, Laurel Finster, Noah M. Merin, Akil Merchant, Karen L. Reckamp, Gil Y. Melmed, Jonathan Braun, Dermot Mcgovern, Samir Parekh, Douglas A. Corley, Namvar Zohoori, Benjamin C. Amick, Ruofei Du, Peter K. Gregersen, Betty DiamondEmanuela Taioli, Carlos Sariol, Ana Espino, Daniela Weiskopf, Alba Gifoni, James Brien, William Hanege, Marc Lipsitch, David A. Zidar, Ann Scheck Mcalearney, Ania Wajnberg, Joshua Labaer, E. Yvonne Lewis, Raquel A. Binder, Ann M. Moormann, Catherine Forconi, Sarah Forrester, Jennifer Batista, John Schieffelin, Dongjoo Kim, Giulia Biancon, Jennifer Vanoudenhove, Stephanie Halene, Rong Fan, Dan H. Barouch, Galit Alter, Swetha Pinninti, Suresh B. Boppana, Sunil K. Pati, Misty Latting, Andrew H. Karaba, John Roback, Rafick Sekaly, Andrew Neish, Ahnalee M. Brincks, Douglas A. Granger, Amy B. Karger, Bharat Thyagarajan, Stefani N. Thomas, Sabra L. Klein, Andrea L. Cox, Todd Lucas, Debra Furr-Holden, Kent Key, Nicole Jones, Jens Wrammerr, Mehul Suthar, Serre Yu Wong, Natalie M. Bowman, Viviana Simon, Lynne D. Richardson, Russell Mcbride, Florian Krammer, Meenakshi Rana, Joshua Kennedy, Karl Boehme, Craig Forrest, Steve W. Granger, Christopher D. Heaney, Maria Knight Lapinski, Shannon Wallet, Ralph S. Baric, Luca Schifanella, Marcos Lopez, Soledad Fernandez, Eben Kenah, Ashish R. Panchal, William J. Britt, Iñaki Sanz, Madhav Dhodapkar, Rafi Ahmed, Luther A. Bartelt, Alena J. Markmann, Jessica T. Lin, Robert S. Hagan, Matthew C. Wolfgang, Jacek Skarbinski

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Global efforts are needed to elucidate the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the underlying cause of coronavirus disease 2019 (COVID-19), including seroprevalence, risk factors, and long-Term sequelae, as well as immune responses after vaccination across populations and the social dimensions of prevention and treatment strategies. Methods: In the United States, the National Cancer Institute in partnership with the National Institute of Allergy and Infectious Diseases, established the SARS-CoV-2 Serological Sciences Network (SeroNet) as the nation's largest coordinated effort to study coronavirus disease 2019. The network comprises multidisciplinary researchers bridging gaps and fostering collaborations among immunologists, epidemiologists, virologists, clinicians and clinical laboratories, social and behavioral scientists, policymakers, data scientists, and community members. In total, 49 institutions form the SeroNet consortium to study individuals with cancer, autoimmune disease, inflammatory bowel diseases, cardiovascular diseases, human immunodeficiency virus, transplant recipients, as well as otherwise healthy pregnant women, children, college students, and high-risk occupational workers (including healthcare workers and first responders). Results: Several studies focus on underrepresented populations, including ethnic minorities and rural communities. To support integrative data analyses across SeroNet studies, efforts are underway to define common data elements for standardized serology measurements, cellular and molecular assays, self-reported data, treatment, and clinical outcomes. Conclusions: In this paper, we discuss the overarching framework for SeroNet epidemiology studies, critical research questions under investigation, and data accessibility for the worldwide scientific community. Lessons learned will help inform preparedness and responsiveness to future emerging diseases.

Original languageEnglish
Article numberofac171
JournalOpen Forum Infectious Diseases
Issue number6
StatePublished - 1 Jun 2022


  • Cohort
  • Covid-19
  • Epidemiology
  • Sars-cov-2
  • Seronet
  • Serosurveillance


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