miRNA regulation of LDL-cholesterol metabolism

Leigh Goedeke, Alexandre Wagschal, Carlos Fernández-Hernando, Anders M. Näär

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


In the past decade, microRNAs (miRNAs) have emerged as key regulators of circulating levels of lipoproteins. Specifically, recent work has uncovered the role of miRNAs in controlling the levels of atherogenic low-density lipoprotein LDL (LDL)-cholesterol by post-transcriptionally regulating genes involved in very low-density lipoprotein (VLDL) secretion, cholesterol biosynthesis, and hepatic LDL receptor (LDLR) expression. Interestingly, several of these miRNAs are located in genomic loci associated with abnormal levels of circulating lipids in humans. These findings reinforce the interest of targeting this subset of non-coding RNAs as potential therapeutic avenues for regulating plasma cholesterol and triglyceride (TAG) levels. In this review, we will discuss how these new miRNAs represent potential pre-disposition factors for cardiovascular disease (CVD), and putative therapeutic targets in patients with cardiometabolic disorders. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.

Original languageEnglish
Pages (from-to)2047-2052
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number12
StatePublished - 1 Dec 2016
Externally publishedYes


  • GWAS
  • LDL
  • LDLR
  • cholesterol
  • lipid
  • miRNA


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