Minireview: Parathyroid hormone-related protein as an intracrine factor - Trafficking mechanisms and functional consequences

Nathalie M. Fiaschi-Taesch, Andrew F. Stewart

Research output: Contribution to journalShort surveypeer-review

99 Scopus citations

Abstract

PTH-related protein (PTHrP) was originally discovered as the factor responsible for humoral hypercalcemia of malignancy. PTHrP is produced by most cell types and is a prohormone that gives rise to a family of mature secretory forms arising from posttranslational endoproteolytic cleavage of the initial translation product. Each of these secretory forms of PTHrP is believed to have one or more of its own receptors on the cell surface that mediates the normal paracrine, autocrine, and endocrine actions of PTHrP. Recently, evidence has accumulated that indicates that PTHrP is also able to enter the nucleus and/or the nucleolus and influence cellular events in an intracrine fashion. This review discusses the mechanisms by which PTHrP may gain access to the nucleus/nucleolus and the functional consequences of this nuclear entry by PTHrP.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalEndocrinology
Volume144
Issue number2
DOIs
StatePublished - 1 Feb 2003
Externally publishedYes

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