Minimally invasive local therapies for liver cancer

David Li, Josephine Kang, Benjamin J. Golas, Vincent W. Yeung, David C. Madof

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Primary and metastatic liver tumors are an increasing global health problem, with hepatocellular carcinoma (HCC) now being the third leading cause of cancer-related mortality worldwide. Systemic treatment options for HCC remain limited, with Sorafenib as the only prospectively validated agent shown to increase overall survival. Surgical resection and/or transplantation, locally ablative therapies and regional or locoregional therapies have filled the gap in liver tumor treatments, providing improved survival outcomes for both primary and metastatic tumors. Minimally invasive local therapies have an increasing role in the treatment of both primary and metastatic liver tumors. For patients with low volume disease, these therapies have now been established into consensus practice guidelines. This review highlights technical aspects and outcomes of commonly utilized, minimally invasive local therapies including laparoscopic liver resection (LLR), radiofrequency ablation (RFA), microwave ablation (MWA), high-intensity focused ultrasound (HIFU), irreversible electroporation (IRE), and stereotactic body radiation therapy (SBRT). In addition, the role of combination treatment strategies utilizing these minimally invasive techniques is reviewed.

Original languageEnglish
Pages (from-to)217-236
Number of pages20
JournalCancer Biology and Medicine
Volume11
Issue number4
DOIs
StatePublished - 1 Dec 2014
Externally publishedYes

Keywords

  • Hepatocellular carcinoma (HCC)
  • Liver
  • Metastasis

Fingerprint

Dive into the research topics of 'Minimally invasive local therapies for liver cancer'. Together they form a unique fingerprint.

Cite this