TY - JOUR
T1 - Million Veteran Program
T2 - A mega-biobank to study genetic influences on health and disease
AU - Gaziano, John Michael
AU - Concato, John
AU - Brophy, Mary
AU - Fiore, Louis
AU - Pyarajan, Saiju
AU - Breeling, James
AU - Whitbourne, Stacey
AU - Deen, Jennifer
AU - Shannon, Colleen
AU - Humphries, Donald
AU - Guarino, Peter
AU - Aslan, Mihaela
AU - Anderson, Daniel
AU - Lafleur, Rene
AU - Hammond, Timothy
AU - Schaa, Kendra
AU - Moser, Jennifer
AU - Huang, Grant
AU - Muralidhar, Sumitra
AU - Przygodzki, Ronald
AU - O'Leary, Timothy J.
N1 - Funding Information:
Funding: The research was funded by the Office of Research and Development , Department of Veterans Affairs.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objective To describe the design and ongoing conduct of the Million Veteran Program (MVP), as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) health care system. Study Design and Setting Data are being collected from participants using questionnaires, the VA electronic health record, and a blood sample for genomic and other testing. Several ongoing projects are linked to MVP, both as peer-reviewed research studies and as activities to help develop an infrastructure for future, broad-based research uses. Results Formal planning for MVP commenced in 2009; the protocol was approved in 2010, and enrollment began in 2011. As of August 3, 2015, and with a steady state of ≈50 recruiting sites nationwide, N = 397,104 veterans have been enrolled. Among N = 199,348 with currently available genotyping data, most participants (as expected) are male (92.0%) between the ages of 50 and 69 years (55.0%). On the basis of self-reported race, white (77.2%) and African American (13.5%) populations are well represented. Conclusions By helping to promote the future integration of genetic testing in health care delivery, including clinical decision making, the MVP is designed to contribute to the development of precision medicine.
AB - Objective To describe the design and ongoing conduct of the Million Veteran Program (MVP), as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) health care system. Study Design and Setting Data are being collected from participants using questionnaires, the VA electronic health record, and a blood sample for genomic and other testing. Several ongoing projects are linked to MVP, both as peer-reviewed research studies and as activities to help develop an infrastructure for future, broad-based research uses. Results Formal planning for MVP commenced in 2009; the protocol was approved in 2010, and enrollment began in 2011. As of August 3, 2015, and with a steady state of ≈50 recruiting sites nationwide, N = 397,104 veterans have been enrolled. Among N = 199,348 with currently available genotyping data, most participants (as expected) are male (92.0%) between the ages of 50 and 69 years (55.0%). On the basis of self-reported race, white (77.2%) and African American (13.5%) populations are well represented. Conclusions By helping to promote the future integration of genetic testing in health care delivery, including clinical decision making, the MVP is designed to contribute to the development of precision medicine.
KW - Cohort studies
KW - Exome sequencing
KW - Genomics
KW - Genotyping
KW - Veterans
KW - Whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=84957436835&partnerID=8YFLogxK
U2 - 10.1016/j.jclinepi.2015.09.016
DO - 10.1016/j.jclinepi.2015.09.016
M3 - Article
C2 - 26441289
AN - SCOPUS:84957436835
SN - 0895-4356
VL - 70
SP - 214
EP - 223
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
ER -