TY - JOUR
T1 - Migraine models.
AU - Benemei, Silvia
AU - De Cesaris, Francesco
AU - Nicoletti, Paola
AU - Materazzi, Serena
AU - Nassini, Romina
AU - Geppetti, Pierangelo
PY - 2010
Y1 - 2010
N2 - Migraine is a high prevalence disorder which affects a significant proportion of the general population, especially women during their central and more productive time of the life, thus causing severe disability. The genetic basis of the disease is unknown and the mechanism is poorly understood. The possibility that following a perturbation in the central nervous system, and particularly in the brainstem, trigeminal neurons become hyperexcitable and produce an uncontrolled release of sensory neuropeptides which eventually results in arterial vasodilatation and neuronal sensitization, has been gaining credit from studies in experimental animals and humans. In particular, experimental and clinical data with antagonists of the calcitonin gene-related peptide (CGRP) propose this molecule and its receptor as a major target for migraine treatment.
AB - Migraine is a high prevalence disorder which affects a significant proportion of the general population, especially women during their central and more productive time of the life, thus causing severe disability. The genetic basis of the disease is unknown and the mechanism is poorly understood. The possibility that following a perturbation in the central nervous system, and particularly in the brainstem, trigeminal neurons become hyperexcitable and produce an uncontrolled release of sensory neuropeptides which eventually results in arterial vasodilatation and neuronal sensitization, has been gaining credit from studies in experimental animals and humans. In particular, experimental and clinical data with antagonists of the calcitonin gene-related peptide (CGRP) propose this molecule and its receptor as a major target for migraine treatment.
UR - http://www.scopus.com/inward/record.url?scp=77953085643&partnerID=8YFLogxK
U2 - 10.1007/978-1-60327-323-7_9
DO - 10.1007/978-1-60327-323-7_9
M3 - Article
C2 - 20336417
AN - SCOPUS:77953085643
SN - 1064-3745
VL - 617
SP - 105
EP - 114
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -