Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography

Yuk Kee Cheung; Evren U. Azeloglu; David A. Shiovitz; Kevin D. Costa; Dror Seliktar; Samuel K. Sia

doi:10.1002/anie.200900807

Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography

Yuk Kee Cheung, Evren U. Azeloglu, David A. Shiovitz, Kevin D. Costa, Dror Seliktar, Samuel K. Sia

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Microfluidics-based lithography based on microfluidics is used to pattern cell-adhesive hydrogel substrates with micro-variations in stiffness. The micropatterns are generated by feeding PEG-fibrinogen and various amounts of polyethylene glycol diacrylate (PEGDA) into the micofluidic channel (see picture).

Original language	English
Pages (from-to)	7188-7192
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	39
DOIs	https://doi.org/10.1002/anie.200900807
State	Published - 14 Sep 2009
Externally published	Yes

Keywords

Hydrogels
Mechanosensing
Micofluidics
Microfabrication
Polymerization

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10.1002/anie.200900807

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title = "Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography",

abstract = "Microfluidics-based lithography based on microfluidics is used to pattern cell-adhesive hydrogel substrates with micro-variations in stiffness. The micropatterns are generated by feeding PEG-fibrinogen and various amounts of polyethylene glycol diacrylate (PEGDA) into the micofluidic channel (see picture).",

keywords = "Hydrogels, Mechanosensing, Micofluidics, Microfabrication, Polymerization",

author = "Cheung, \{Yuk Kee\} and Azeloglu, \{Evren U.\} and Shiovitz, \{David A.\} and Costa, \{Kevin D.\} and Dror Seliktar and Sia, \{Samuel K.\}",

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AU - Cheung, Yuk Kee

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AU - Shiovitz, David A.

AU - Costa, Kevin D.

AU - Seliktar, Dror

AU - Sia, Samuel K.

PY - 2009/9/14

Y1 - 2009/9/14

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AB - Microfluidics-based lithography based on microfluidics is used to pattern cell-adhesive hydrogel substrates with micro-variations in stiffness. The micropatterns are generated by feeding PEG-fibrinogen and various amounts of polyethylene glycol diacrylate (PEGDA) into the micofluidic channel (see picture).

KW - Hydrogels

KW - Mechanosensing

KW - Micofluidics

KW - Microfabrication

KW - Polymerization

UR - https://www.scopus.com/pages/publications/70349782333

U2 - 10.1002/anie.200900807

DO - 10.1002/anie.200900807

M3 - Article

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AN - SCOPUS:70349782333

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JF - Angewandte Chemie - International Edition

IS - 39

ER -

Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography

Abstract

Keywords

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