Micrornas and calcium signaling in heart disease

Jae Ho Park, Changwon Kho

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

In hearts, calcium (Ca2+) signaling is a crucial regulatory mechanism of muscle contraction and electrical signals that determine heart rhythm and control cell growth. Ca2+ signals must be tightly controlled for a healthy heart, and the impairment of Ca2+ handling proteins is a key hallmark of heart disease. The discovery of microRNA (miRNAs) as a new class of gene regulators has greatly expanded our understanding of the controlling module of cardiac Ca2+ cycling. Furthermore, many studies have explored the involvement of miRNAs in heart diseases. In this review, we aim to summarize cardiac Ca2+ signaling and Ca2+-related miRNAs in pathological conditions, including cardiac hypertrophy, heart failure, myocardial infarction, and atrial fibrillation. We also discuss the therapeutic potential of Ca2+-related miRNAs as a new target for the treatment of heart diseases.

Original languageEnglish
Article number10582
JournalInternational Journal of Molecular Sciences
Volume22
Issue number19
DOIs
StatePublished - 1 Oct 2021
Externally publishedYes

Keywords

  • Atrial fibrillation
  • Calcium signaling
  • Cardiac hypertrophy
  • Heart failure
  • MicroRNA
  • Myocardial infarction

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