TY - JOUR
T1 - MicroRNA regulation of lipoprotein metabolism
AU - Goedeke, Leigh
AU - Aranda, Juan F.
AU - Fernández-Hernando, Carlos
PY - 2014/8
Y1 - 2014/8
N2 - PURPOSE OF REVIEW: The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels. RECENT FINDINGS: In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1. SUMMARY: The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.
AB - PURPOSE OF REVIEW: The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels. RECENT FINDINGS: In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1. SUMMARY: The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.
KW - cholesterol homeostasis
KW - lipoprotein metabolism
KW - miRNAs
UR - http://www.scopus.com/inward/record.url?scp=84904187248&partnerID=8YFLogxK
U2 - 10.1097/MOL.0000000000000094
DO - 10.1097/MOL.0000000000000094
M3 - Review article
AN - SCOPUS:84904187248
SN - 0957-9672
VL - 25
SP - 282
EP - 288
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
IS - 4
ER -