MicroRNA regulation of lipoprotein metabolism

Leigh Goedeke, Juan F. Aranda, Carlos Fernández-Hernando

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

PURPOSE OF REVIEW: The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels. RECENT FINDINGS: In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1. SUMMARY: The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalCurrent Opinion in Lipidology
Volume25
Issue number4
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • cholesterol homeostasis
  • lipoprotein metabolism
  • miRNAs

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