Microglandular Adenosis: A Possible Non-Obligate Precursor to Breast Carcinoma With Potential to Either Luminal-Type or Basal-Type Differentiation

Alexander T. Damron, Katrina Korhonen, Samantha Zuckerman, Julia Tchou, Kimberly L. Dumoff, Ira J. Bleiweiss, Anupma Nayak

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Microglandular adenosis (MGA) of the breast is exceedingly rare, with only a few case reports and series published to date. Previous studies have elegantly demonstrated the progression of benign MGA to atypical MGA to MGA-in situ carcinoma to invasive carcinoma and therefore suggest MGA as a possible non-obligate precursor lesion to a subset of breast carcinomas. Immunohistochemically, MGA is negative for estrogen receptor (ER), progesterone receptor (PR), and HER2-neu oncoprotein expression, and carcinomas arising in the setting of MGA are often reported to be triple negative. In this article, we present a unique case of an ER+/PR+/HER2− invasive carcinoma associated with MGA and atypical MGA. Our case highlights the diagnostic pitfall of MGA and suggests that MGA is a heterogeneous group of lesions with potential for either luminal-type or basal-type differentiation during progression to breast carcinoma.

Original languageEnglish
Pages (from-to)781-787
Number of pages7
JournalInternational Journal of Surgical Pathology
Volume27
Issue number7
DOIs
StatePublished - 1 Oct 2019
Externally publishedYes

Keywords

  • MGA
  • MGA carcinoma
  • MGA in situ
  • atypical microglandular adenosis
  • microglandular adenosis
  • microglandular adenosis biomarkers
  • microglandular adenosis estrogen receptor
  • microglandular adenosis immunohistochemistry
  • microglandular adenosis precursor

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