Microelectrophoresis of biogenic amines on hypothalamic thermosensitive cells

Alexander L. Beckman, Joseph S. Eisenman

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The rat hypothalamus contains thermally insensitive, normally sensisitive, and highly thermosensitive cells. The responses of thermosensitive neurons to microelectrophoretically applied acetylcholine, norepinephrine, and 5-hydroxytryptamine were the same in both rats and cats. The firing rate of warm-sensitive interneurons was accelerated by acetylcholine and inhibited by norepinephrine. The firing rate of cool-sensitive interneurons was accelerated by norepinephrine and, in one case, was inhibited by 5-hydroxytryptamine. Thermodetector cells were relatively insensitive to these amines, but were sensitive to current flow. These results from the rat, but not from the cat, agree with the data for thermoregulatory responses following microinjection of these amines into the hypothalamus.

Original languageEnglish
Pages (from-to)334-336
Number of pages3
Issue number3955
StatePublished - 1970
Externally publishedYes


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