TY - JOUR
T1 - Microelectrophoresis of biogenic amines on hypothalamic thermosensitive cells
AU - Beckman, Alexander L.
AU - Eisenman, Joseph S.
PY - 1970
Y1 - 1970
N2 - The rat hypothalamus contains thermally insensitive, normally sensisitive, and highly thermosensitive cells. The responses of thermosensitive neurons to microelectrophoretically applied acetylcholine, norepinephrine, and 5-hydroxytryptamine were the same in both rats and cats. The firing rate of warm-sensitive interneurons was accelerated by acetylcholine and inhibited by norepinephrine. The firing rate of cool-sensitive interneurons was accelerated by norepinephrine and, in one case, was inhibited by 5-hydroxytryptamine. Thermodetector cells were relatively insensitive to these amines, but were sensitive to current flow. These results from the rat, but not from the cat, agree with the data for thermoregulatory responses following microinjection of these amines into the hypothalamus.
AB - The rat hypothalamus contains thermally insensitive, normally sensisitive, and highly thermosensitive cells. The responses of thermosensitive neurons to microelectrophoretically applied acetylcholine, norepinephrine, and 5-hydroxytryptamine were the same in both rats and cats. The firing rate of warm-sensitive interneurons was accelerated by acetylcholine and inhibited by norepinephrine. The firing rate of cool-sensitive interneurons was accelerated by norepinephrine and, in one case, was inhibited by 5-hydroxytryptamine. Thermodetector cells were relatively insensitive to these amines, but were sensitive to current flow. These results from the rat, but not from the cat, agree with the data for thermoregulatory responses following microinjection of these amines into the hypothalamus.
UR - http://www.scopus.com/inward/record.url?scp=0014952118&partnerID=8YFLogxK
U2 - 10.1126/science.170.3955.334
DO - 10.1126/science.170.3955.334
M3 - Article
C2 - 5460038
AN - SCOPUS:0014952118
SN - 0036-8075
VL - 170
SP - 334
EP - 336
JO - Science
JF - Science
IS - 3955
ER -