Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

Aitor Blanco-Míguez; Sara Carloni; Cindy Cardenas; Carola Conca Dioguardi; Luca Lambroia; Giovanni Capretti; Gennaro Nappo; Alessandro Fugazza; Antonio Capogreco; Federica Armanini; Francesco Asnicar; Leonard Dubois; Davide Golzato; Paolo Manghi; Federica Pinto; Cristina Scuderi; Erminia Casari; Marco Montorsi; Andrea Anderloni; Maria Rescigno; Alessandro Repici; Alessandro Zerbi; Clelia Peano; Sabrina Tamburini; Roberto Rusconi; Nicola Segata

doi:10.1038/s41522-024-00506-8

Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

Aitor Blanco-Míguez
, Sara Carloni
, Cindy Cardenas
, Carola Conca Dioguardi
, Luca Lambroia
, Giovanni Capretti
, Gennaro Nappo
, Alessandro Fugazza
, Antonio Capogreco
, Federica Armanini
, Francesco Asnicar
, Leonard Dubois
, Davide Golzato
, Paolo Manghi
, Federica Pinto
, Cristina Scuderi
, Erminia Casari
, Marco Montorsi
, Andrea Anderloni
, Maria Rescigno

Alessandro Repici, Alessandro Zerbi, Clelia Peano, Sabrina Tamburini, Roberto Rusconi, Nicola Segata

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.

Original language	English
Article number	35
Journal	npj Biofilms and Microbiomes
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41522-024-00506-8
State	Published - Dec 2024
Externally published	Yes

Access to Document

10.1038/s41522-024-00506-8

Cite this

Blanco-Míguez, A., Carloni, S., Cardenas, C., Dioguardi, C. C., Lambroia, L., Capretti, G., Nappo, G., Fugazza, A., Capogreco, A., Armanini, F., Asnicar, F., Dubois, L., Golzato, D., Manghi, P., Pinto, F., Scuderi, C., Casari, E., Montorsi, M., Anderloni, A., ... Segata, N. (2024). Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer. npj Biofilms and Microbiomes, 10(1), Article 35. https://doi.org/10.1038/s41522-024-00506-8

@article{fe8e52c681c54c9abaebf03243984317,

title = "Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer",

abstract = "Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.",

author = "Aitor Blanco-M{\'i}guez and Sara Carloni and Cindy Cardenas and Dioguardi, \{Carola Conca\} and Luca Lambroia and Giovanni Capretti and Gennaro Nappo and Alessandro Fugazza and Antonio Capogreco and Federica Armanini and Francesco Asnicar and Leonard Dubois and Davide Golzato and Paolo Manghi and Federica Pinto and Cristina Scuderi and Erminia Casari and Marco Montorsi and Andrea Anderloni and Maria Rescigno and Alessandro Repici and Alessandro Zerbi and Clelia Peano and Sabrina Tamburini and Roberto Rusconi and Nicola Segata",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41522-024-00506-8",

language = "English",

volume = "10",

journal = "npj Biofilms and Microbiomes",

issn = "2055-5008",

publisher = "Nature Research",

number = "1",

}

Blanco-Míguez, A, Carloni, S, Cardenas, C, Dioguardi, CC, Lambroia, L, Capretti, G, Nappo, G, Fugazza, A, Capogreco, A, Armanini, F, Asnicar, F, Dubois, L, Golzato, D, Manghi, P, Pinto, F, Scuderi, C, Casari, E, Montorsi, M, Anderloni, A, Rescigno, M, Repici, A, Zerbi, A, Peano, C, Tamburini, S, Rusconi, R & Segata, N 2024, 'Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer', npj Biofilms and Microbiomes, vol. 10, no. 1, 35. https://doi.org/10.1038/s41522-024-00506-8

TY - JOUR

T1 - Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

AU - Blanco-Míguez, Aitor

AU - Carloni, Sara

AU - Cardenas, Cindy

AU - Dioguardi, Carola Conca

AU - Lambroia, Luca

AU - Capretti, Giovanni

AU - Nappo, Gennaro

AU - Fugazza, Alessandro

AU - Capogreco, Antonio

AU - Armanini, Federica

AU - Asnicar, Francesco

AU - Dubois, Leonard

AU - Golzato, Davide

AU - Manghi, Paolo

AU - Pinto, Federica

AU - Scuderi, Cristina

AU - Casari, Erminia

AU - Montorsi, Marco

AU - Anderloni, Andrea

AU - Rescigno, Maria

AU - Repici, Alessandro

AU - Zerbi, Alessandro

AU - Peano, Clelia

AU - Tamburini, Sabrina

AU - Rusconi, Roberto

AU - Segata, Nicola

PY - 2024/12

Y1 - 2024/12

N2 - Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.

AB - Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.

UR - https://www.scopus.com/pages/publications/85189025143

U2 - 10.1038/s41522-024-00506-8

DO - 10.1038/s41522-024-00506-8

M3 - Article

AN - SCOPUS:85189025143

SN - 2055-5008

VL - 10

JO - npj Biofilms and Microbiomes

JF - npj Biofilms and Microbiomes

IS - 1

M1 - 35

ER -

Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

Abstract

Access to Document

Fingerprint

Cite this