Microbe-host interactions are positively and negatively regulated by galectin-glycan interactions

Linda G. Baum, Omai B. Garner, Katrin Schaefer, Benhur Lee

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

Microbe-host interactions are complex processes that are directly and indirectly regulated by a variety of factors, including microbe presentation of specific molecular signatures on the microbial surface, as well as host cell presentation of receptors that recognize these pathogen signatures. Cell surface glycans are one important class of microbial signatures that are recognized by a variety of host cell lectins. Host cell lectins that recognize microbial glycans include members of the galectin family of lectins that recognize specific glycan ligands on viruses, bacteria, fungi, and parasites. In this review, we will discuss the ways that the interactions of microbial glycans with host cell galectins positively and negatively regulate pathogen attachment, invasion, and survival, as well as regulate host responses that mitigate microbial pathogenesis.

Original languageEnglish
Article number284
JournalFrontiers in Immunology
Volume5
Issue numberJUN
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Bacteria
  • Cell surface glycans
  • Galectin
  • Microbial pathogen
  • Virus

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