Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with mitomycin C and 5‐fluorouracil

Subhash C. Gulati; Peter Sordillo; Sanford Kempin; Lilian Reich; Gordon B. Magill; Ellen Scheiner; Bayard Clarkson

doi:10.1002/1097-0142(19800501)45:9<2252::AID-CNCR2820450906>3.0.CO;2-N

Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with mitomycin C and 5‐fluorouracil

Subhash C. Gulati, Peter Sordillo, Sanford Kempin, Lilian Reich, Gordon B. Magill, Ellen Scheiner, Bayard Clarkson

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Abstract

Two patients with epidermoid carcinoma treated with mitomycin‐C (Mit‐C) and 5‐fluorouracil (5‐FU) developed microangiopathic hemolytic anemia (MAHA), renal failure, and altered mental status. Patient 1 was free of metastatic disease, on maintenance Mit‐C and 5‐FU when MAHA changes appeared. Patient 2 had recurrent carcinoma in the pelvic area when MAHA changes appeared. In both patients, MAHA changes and neurologic function improved after exchange plasmapheresis. This is the first report of epidermoid carcinoma manifesting MAHA changes after chemotherapy. Speculation as to pathogenesis and appropriate therapy are discussed.

Original language	English
Pages (from-to)	2252-2257
Number of pages	6
Journal	Cancer
Volume	45
Issue number	9
DOIs	https://doi.org/10.1002/1097-0142(19800501)45:9<2252::AID-CNCR2820450906>3.0.CO;2-N
State	Published - 1 May 1980
Externally published	Yes

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title = "Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with mitomycin C and 5‐fluorouracil",

abstract = "Two patients with epidermoid carcinoma treated with mitomycin‐C (Mit‐C) and 5‐fluorouracil (5‐FU) developed microangiopathic hemolytic anemia (MAHA), renal failure, and altered mental status. Patient 1 was free of metastatic disease, on maintenance Mit‐C and 5‐FU when MAHA changes appeared. Patient 2 had recurrent carcinoma in the pelvic area when MAHA changes appeared. In both patients, MAHA changes and neurologic function improved after exchange plasmapheresis. This is the first report of epidermoid carcinoma manifesting MAHA changes after chemotherapy. Speculation as to pathogenesis and appropriate therapy are discussed.",

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T1 - Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with mitomycin C and 5‐fluorouracil

AU - Gulati, Subhash C.

AU - Sordillo, Peter

AU - Kempin, Sanford

AU - Reich, Lilian

AU - Magill, Gordon B.

AU - Scheiner, Ellen

AU - Clarkson, Bayard

PY - 1980/5/1

Y1 - 1980/5/1

N2 - Two patients with epidermoid carcinoma treated with mitomycin‐C (Mit‐C) and 5‐fluorouracil (5‐FU) developed microangiopathic hemolytic anemia (MAHA), renal failure, and altered mental status. Patient 1 was free of metastatic disease, on maintenance Mit‐C and 5‐FU when MAHA changes appeared. Patient 2 had recurrent carcinoma in the pelvic area when MAHA changes appeared. In both patients, MAHA changes and neurologic function improved after exchange plasmapheresis. This is the first report of epidermoid carcinoma manifesting MAHA changes after chemotherapy. Speculation as to pathogenesis and appropriate therapy are discussed.

AB - Two patients with epidermoid carcinoma treated with mitomycin‐C (Mit‐C) and 5‐fluorouracil (5‐FU) developed microangiopathic hemolytic anemia (MAHA), renal failure, and altered mental status. Patient 1 was free of metastatic disease, on maintenance Mit‐C and 5‐FU when MAHA changes appeared. Patient 2 had recurrent carcinoma in the pelvic area when MAHA changes appeared. In both patients, MAHA changes and neurologic function improved after exchange plasmapheresis. This is the first report of epidermoid carcinoma manifesting MAHA changes after chemotherapy. Speculation as to pathogenesis and appropriate therapy are discussed.

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DO - 10.1002/1097-0142(19800501)45:9<2252::AID-CNCR2820450906>3.0.CO;2-N

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JO - Cancer

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Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with mitomycin C and 5‐fluorouracil

Abstract

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