Mice cloned from olfactory sensory neurons

Kevin Eggan, Kristin Baldwin, Michael Tackett, Joseph Osborne, Joseph Gogos, Andrew Chess, Richard Axel, Rudolf Jaenisch

Research output: Contribution to journalArticlepeer-review

313 Scopus citations

Abstract

Cloning by nuclear transplantation has been successfully carried out in various mammals, including mice. Until now mice have not been cloned from post-mitotic cells such as neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of odorant receptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguishable from wild-type animals, indicating that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalNature
Volume428
Issue number6978
DOIs
StatePublished - 4 Mar 2004
Externally publishedYes

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