@article{b08e7f606b594f5da8d7272e777bccd7,
title = "Methylphenidate decreases regional cerebral blood flow in normal human subjects",
abstract = "To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25±11%) and at 30 minutes (20±10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.",
author = "Wang, {Gene Jack} and Volkow, {Nora D.} and Fowler, {Joanna S.} and Richard Ferrieri and Schlyer, {David J.} and David Alexoff and Naomi Pappas and Jeffrey Lieberman and Payton King and Donald Warner and Christopher Wong and Hitzemann, {Robert J.} and Wolf, {Alfred P.}",
note = "Funding Information: This work was supported by U.S. Department of Energy under contract DE-AC02-76CH00016 and NIH NS 15638. The authors thank C. Barrette, R. Carciello, K. Johannesen, T. Johnson, R. MacGregor, T. Martin, N. Netusil, C. Redvanly, C. Shea for their participation in various aspects of this work.",
year = "1994",
doi = "10.1016/0024-3205(94)00873-6",
language = "English",
volume = "54",
pages = "PL143--PL146",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "9",
}