Methylphenidate and continuous spike and wave during sleep in a child with attention deficit hyperactivity disorder

Volney L. Sheen, Maithreyi Shankar, Isaac Marin-Valencia, Carolyn H. Bridgemohan, Alcy R. Torres

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Attention-deficit/hyperactivity disorder is the most common neurobehavioral disorder in children and frequently associated with epilepsy. For patients with both conditions, methylphenidate remains a mainstay in the treatment of behavioral problems. Most studies demonstrate that methylphenidate is effective in treating children with well-controlled epilepsy, and that methylphenidate does not increase the risk of having seizures in patients with EEG abnormalities without epilepsy. However, in patients with active seizures, the results are somewhat contradictory. This article presents the case of a young girl with attention-deficit/hyperactivity disorder and behavioral problems on Depakote (valproic acid) who had an abnormal EEG with left centroparietal spikes but no history of electrographic seizures. She experienced a convulsion the day after her first dose of methylphenidate, and repeat EEG demonstrated continuous spike and slow wave during sleep. This case report suggests that children with continuous spike and slow wave during sleep may have a higher risk of developing seizures with methylphenidate treatment.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalPediatric Neurology
Volume49
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

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