Methyl-Analyzer-whole genome DNA methylation profiling

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Abstract

Summary: Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS (methylation mapping analysis by paired-end sequencing) method. Methyl-MAPS is an enzymatic-based method that uses both methylation-sensitive and -dependent enzymes covering >80% of CpG dinucleotides within mammalian genomes. It combines enzymatic-based approaches with high-throughput next-generation sequencing technology to provide whole genome DNA methylation profiles. Methyl-Analyzer processes and integrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation probabilities at single base resolution.

Original languageEnglish
Article numberbtr356
Pages (from-to)2296-2297
Number of pages2
JournalBioinformatics
Volume27
Issue number16
DOIs
StatePublished - Aug 2011

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