Methotrexate in the Treatment of Ulcerative Colitis

Ellen J. Scherl; Vinita Elizabeth Jacob; Brian P. Bosworth; Ryan Urquhart Warren; Harrison Lakehomer

doi:10.1201/9781003526827-23

Methotrexate in the Treatment of Ulcerative Colitis

Ellen J. Scherl
, Vinita Elizabeth Jacob
, Brian P. Bosworth
, Ryan Urquhart Warren
, Harrison Lakehomer

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Methotrexate, a folate antagonist and potent anti-inflammatory agent, is an analog of dihydrofolic acid that inhibits dihydrofolate reductase and folate-dependent enzymes that are pivotal in the synthesis of purines and pyrimidines. 1-3 It is an effective therapy in rheumatoid arthritis, Crohn's disease, and psoriasis. 4-9 The efficacy of methotrexate in the treatment of ulcerative colitis (UC) is not yet established.

Original language	English
Title of host publication	Ulcerative Colitis
Subtitle of host publication	The Complete Guide to Medical Management
Publisher	CRC Press
Pages	221-225
Number of pages	5
ISBN (Electronic)	9781040140468
ISBN (Print)	9781556429453
DOIs	https://doi.org/10.1201/9781003526827-23
State	Published - 1 Jan 2024
Externally published	Yes

Access to Document

10.1201/9781003526827-23

Cite this

@inbook{8ba2373b468244ed8b7eee5b32fa4da0,

title = "Methotrexate in the Treatment of Ulcerative Colitis",

abstract = "Methotrexate, a folate antagonist and potent anti-inflammatory agent, is an analog of dihydrofolic acid that inhibits dihydrofolate reductase and folate-dependent enzymes that are pivotal in the synthesis of purines and pyrimidines. 1-3 It is an effective therapy in rheumatoid arthritis, Crohn's disease, and psoriasis. 4-9 The efficacy of methotrexate in the treatment of ulcerative colitis (UC) is not yet established.",

author = "Scherl, \{Ellen J.\} and Jacob, \{Vinita Elizabeth\} and Bosworth, \{Brian P.\} and Warren, \{Ryan Urquhart\} and Harrison Lakehomer",

note = "Publisher Copyright: {\textcopyright} 2011 Taylor \& Francis Group.",

year = "2024",

month = jan,

day = "1",

doi = "10.1201/9781003526827-23",

language = "English",

isbn = "9781556429453",

pages = "221--225",

booktitle = "Ulcerative Colitis",

publisher = "CRC Press",

}

TY - CHAP

T1 - Methotrexate in the Treatment of Ulcerative Colitis

AU - Scherl, Ellen J.

AU - Jacob, Vinita Elizabeth

AU - Bosworth, Brian P.

AU - Warren, Ryan Urquhart

AU - Lakehomer, Harrison

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Methotrexate, a folate antagonist and potent anti-inflammatory agent, is an analog of dihydrofolic acid that inhibits dihydrofolate reductase and folate-dependent enzymes that are pivotal in the synthesis of purines and pyrimidines. 1-3 It is an effective therapy in rheumatoid arthritis, Crohn's disease, and psoriasis. 4-9 The efficacy of methotrexate in the treatment of ulcerative colitis (UC) is not yet established.

AB - Methotrexate, a folate antagonist and potent anti-inflammatory agent, is an analog of dihydrofolic acid that inhibits dihydrofolate reductase and folate-dependent enzymes that are pivotal in the synthesis of purines and pyrimidines. 1-3 It is an effective therapy in rheumatoid arthritis, Crohn's disease, and psoriasis. 4-9 The efficacy of methotrexate in the treatment of ulcerative colitis (UC) is not yet established.

UR - https://www.scopus.com/pages/publications/85208011395

U2 - 10.1201/9781003526827-23

DO - 10.1201/9781003526827-23

M3 - Chapter

AN - SCOPUS:85208011395

SN - 9781556429453

SP - 221

EP - 225

BT - Ulcerative Colitis

PB - CRC Press

ER -

Methotrexate in the Treatment of Ulcerative Colitis

Abstract

Access to Document

Fingerprint

Cite this