Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease

Mykayla L. Sandler; Monica H. Xing; Juliana C. Levy; Raymond L. Chai; Azita S. Khorsandi; Camilo Gonzalez-Velazquez; Mark L. Urken

doi:10.1002/hed.26572

Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease

Mykayla L. Sandler, Monica H. Xing, Juliana C. Levy, Raymond L. Chai, Azita S. Khorsandi, Camilo Gonzalez-Velazquez, Mark L. Urken

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Background: Metastatic thyroid carcinoma to retropharyngeal and parapharyngeal (RP/PP) lymph nodes is rare. Literature suggests previous lateral neck dissection (LND) may alter patterns of lymphatic drainage in the neck, predisposing to these less common sites of spread. Methods: PRISMA-guided systematic search for all published cases detailing RP/PP metastases of well-differentiated thyroid carcinoma from 1970 to 2019. Results: Seventy articles were identified and 44 were included, along with seven cases treated at our institution, totaling 239 cases. Cases represented both retropharyngeal (60.7%) and parapharyngeal (39.3%) metastases identified in the initial (27.6%) and recurrent (72.4%) setting. Conclusion: RP/PP metastases generally present in the recurrent setting. RP/PP metastases often represent high-risk disease, and surgical treatment is recommended.

Original language	English
Pages (from-to)	1331-1344
Number of pages	14
Journal	Head and Neck
Volume	43
Issue number	4
DOIs	https://doi.org/10.1002/hed.26572
State	Published - Apr 2021

Keywords

metastasis
papillary thyroid cancer
parapharyngeal space
retropharyngeal space
well-differentiated thyroid cancer

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10.1002/hed.26572

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Sandler, M. L., Xing, M. H., Levy, J. C., Chai, R. L., Khorsandi, A. S., Gonzalez-Velazquez, C., & Urken, M. L. (2021). Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease. Head and Neck, 43(4), 1331-1344. https://doi.org/10.1002/hed.26572

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abstract = "Background: Metastatic thyroid carcinoma to retropharyngeal and parapharyngeal (RP/PP) lymph nodes is rare. Literature suggests previous lateral neck dissection (LND) may alter patterns of lymphatic drainage in the neck, predisposing to these less common sites of spread. Methods: PRISMA-guided systematic search for all published cases detailing RP/PP metastases of well-differentiated thyroid carcinoma from 1970 to 2019. Results: Seventy articles were identified and 44 were included, along with seven cases treated at our institution, totaling 239 cases. Cases represented both retropharyngeal (60.7%) and parapharyngeal (39.3%) metastases identified in the initial (27.6%) and recurrent (72.4%) setting. Conclusion: RP/PP metastases generally present in the recurrent setting. RP/PP metastases often represent high-risk disease, and surgical treatment is recommended.",

keywords = "metastasis, papillary thyroid cancer, parapharyngeal space, retropharyngeal space, well-differentiated thyroid cancer",

author = "Sandler, {Mykayla L.} and Xing, {Monica H.} and Levy, {Juliana C.} and Chai, {Raymond L.} and Khorsandi, {Azita S.} and Camilo Gonzalez-Velazquez and Urken, {Mark L.}",

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Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease. / Sandler, Mykayla L.; Xing, Monica H.; Levy, Juliana C. et al.
In: Head and Neck, Vol. 43, No. 4, 04.2021, p. 1331-1344.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces

T2 - Systematic review with seven newly reported cases describing an uncommon presentation of a common disease

AU - Sandler, Mykayla L.

AU - Xing, Monica H.

AU - Levy, Juliana C.

AU - Chai, Raymond L.

AU - Khorsandi, Azita S.

AU - Gonzalez-Velazquez, Camilo

AU - Urken, Mark L.

PY - 2021/4

Y1 - 2021/4

N2 - Background: Metastatic thyroid carcinoma to retropharyngeal and parapharyngeal (RP/PP) lymph nodes is rare. Literature suggests previous lateral neck dissection (LND) may alter patterns of lymphatic drainage in the neck, predisposing to these less common sites of spread. Methods: PRISMA-guided systematic search for all published cases detailing RP/PP metastases of well-differentiated thyroid carcinoma from 1970 to 2019. Results: Seventy articles were identified and 44 were included, along with seven cases treated at our institution, totaling 239 cases. Cases represented both retropharyngeal (60.7%) and parapharyngeal (39.3%) metastases identified in the initial (27.6%) and recurrent (72.4%) setting. Conclusion: RP/PP metastases generally present in the recurrent setting. RP/PP metastases often represent high-risk disease, and surgical treatment is recommended.

AB - Background: Metastatic thyroid carcinoma to retropharyngeal and parapharyngeal (RP/PP) lymph nodes is rare. Literature suggests previous lateral neck dissection (LND) may alter patterns of lymphatic drainage in the neck, predisposing to these less common sites of spread. Methods: PRISMA-guided systematic search for all published cases detailing RP/PP metastases of well-differentiated thyroid carcinoma from 1970 to 2019. Results: Seventy articles were identified and 44 were included, along with seven cases treated at our institution, totaling 239 cases. Cases represented both retropharyngeal (60.7%) and parapharyngeal (39.3%) metastases identified in the initial (27.6%) and recurrent (72.4%) setting. Conclusion: RP/PP metastases generally present in the recurrent setting. RP/PP metastases often represent high-risk disease, and surgical treatment is recommended.

KW - metastasis

KW - papillary thyroid cancer

KW - parapharyngeal space

KW - retropharyngeal space

KW - well-differentiated thyroid cancer

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DO - 10.1002/hed.26572

M3 - Review article

C2 - 33295689

AN - SCOPUS:85097301551

SN - 1043-3074

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JO - Head and Neck

JF - Head and Neck

IS - 4

ER -

Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease

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Keywords

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