TY - JOUR
T1 - Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease
AU - Polydorides, Alexandros D.
AU - Rosenblum, Marc K.
AU - Edgar, Mark A.
PY - 2007/4
Y1 - 2007/4
N2 - A case of metastatic renal cell carcinoma (RCC) to a capillary hemangioblastonna (HAB) of the central nervous system in a 52-year-old woman with von Hippel-Lindau (vHL) syndrome is described. We review the literature on metastatic RCC to HAB, summarize the histologic and immunohistochemical features that can distinguish between the 2 tumors, and comment on the significance of such a finding in terms of the clinical diagnosis of vHL We found the expression of CAM 5.2, RCC antigen, and CD10 to be strong in RCC and absent in HAB and, conversely, staining with Leu-7, neural cell adhesion molecule, and inhibin-α was present in HAB but weak or absent in RCC. These antibodies can be used to differentiate these entities, provided one is astute in recognizing the possibility of their co-existence.
AB - A case of metastatic renal cell carcinoma (RCC) to a capillary hemangioblastonna (HAB) of the central nervous system in a 52-year-old woman with von Hippel-Lindau (vHL) syndrome is described. We review the literature on metastatic RCC to HAB, summarize the histologic and immunohistochemical features that can distinguish between the 2 tumors, and comment on the significance of such a finding in terms of the clinical diagnosis of vHL We found the expression of CAM 5.2, RCC antigen, and CD10 to be strong in RCC and absent in HAB and, conversely, staining with Leu-7, neural cell adhesion molecule, and inhibin-α was present in HAB but weak or absent in RCC. These antibodies can be used to differentiate these entities, provided one is astute in recognizing the possibility of their co-existence.
UR - http://www.scopus.com/inward/record.url?scp=34147125874&partnerID=8YFLogxK
U2 - 10.5858/2007-131-641-mrccth
DO - 10.5858/2007-131-641-mrccth
M3 - Article
C2 - 17425399
AN - SCOPUS:34147125874
SN - 0003-9985
VL - 131
SP - 641
EP - 645
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 4
ER -