Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease

Alexandros D. Polydorides, Marc K. Rosenblum, Mark A. Edgar

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36 Scopus citations

Abstract

A case of metastatic renal cell carcinoma (RCC) to a capillary hemangioblastonna (HAB) of the central nervous system in a 52-year-old woman with von Hippel-Lindau (vHL) syndrome is described. We review the literature on metastatic RCC to HAB, summarize the histologic and immunohistochemical features that can distinguish between the 2 tumors, and comment on the significance of such a finding in terms of the clinical diagnosis of vHL We found the expression of CAM 5.2, RCC antigen, and CD10 to be strong in RCC and absent in HAB and, conversely, staining with Leu-7, neural cell adhesion molecule, and inhibin-α was present in HAB but weak or absent in RCC. These antibodies can be used to differentiate these entities, provided one is astute in recognizing the possibility of their co-existence.

Original languageEnglish
Pages (from-to)641-645
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume131
Issue number4
StatePublished - Apr 2007
Externally publishedYes

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