Metastasis suppressor genes and their role in the tumor microenvironment

Cristina Megino-Luque, Jose Javier Bravo-Cordero

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.

Original languageEnglish
Pages (from-to)1147-1154
Number of pages8
JournalCancer and Metastasis Reviews
Issue number4
StatePublished - Dec 2023


  • Cancer
  • Metastasis
  • Metastasis suppresor genes
  • Tumor microenvironment


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