Metastasis Organotropism: Redefining the Congenial Soil

Yang Gao, Igor Bado, Hai Wang, Weijie Zhang, Jeffrey M. Rosen, Xiang H.F. Zhang

Research output: Contribution to journalReview articlepeer-review

206 Scopus citations

Abstract

Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as “organotropism.” Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism. Clinical observations suggest that most cancers metastasize to specific organs, a process known as “organotropism.” This Review from Gao et al. highlights recent findings on tumor-intrinsic properties and their interaction with unique cellular, architectural, metabolic, and immune features of host organs, which together determine organ-specific metastatic behaviors.

Original languageEnglish
Pages (from-to)375-391
Number of pages17
JournalDevelopmental Cell
Volume49
Issue number3
DOIs
StatePublished - 6 May 2019
Externally publishedYes

Keywords

  • EMT
  • immune microenvironment
  • metabolism
  • metastasis
  • niche
  • organotropism
  • seed and soil

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