TY - JOUR
T1 - Metabotropic glutamate receptors limit adenylyl cyclase-mediated effects in rat hippocampus via protein kinase C
AU - Nouranifar, Rabin
AU - Blitzer, Robert D.
AU - Wong, Tony
AU - Landau, Emmanuel
N1 - Funding Information:
This work was supported by a NARSAD Grant to R.D.B. and a VA Merit Grant to E.M.L.
PY - 1998/3/13
Y1 - 1998/3/13
N2 - Glutamate receptors of the metabotropic type (mGluRs) activate protein kinase C in hippocampus, but few physiological functions of this pathway are known. The present data show that mGluRs utilize protein kinase C to inhibit another second messenger system, the adenylyl cyclase pathway, in neurons of the CA1 area of hippocampus. Activation of mGluRs prevented β-adrenergic receptors, which couple to adenylyl cyclase, from blocking the slow Ca2+- dependent afterhyperpolarization (AHP). Since the afterhyperpolarization modulates neuronal responsiveness, crosstalk between protein kinase C and the adenylyl cyclase pathway is likely to have physiological consequences. Moreover, mGluRs themselves block the afterhyperpolarization, so the observed interference with the β-adrenergic response constitutes a hierarchical relationship in which mGluRs are dominant over β-adrenergic receptors.
AB - Glutamate receptors of the metabotropic type (mGluRs) activate protein kinase C in hippocampus, but few physiological functions of this pathway are known. The present data show that mGluRs utilize protein kinase C to inhibit another second messenger system, the adenylyl cyclase pathway, in neurons of the CA1 area of hippocampus. Activation of mGluRs prevented β-adrenergic receptors, which couple to adenylyl cyclase, from blocking the slow Ca2+- dependent afterhyperpolarization (AHP). Since the afterhyperpolarization modulates neuronal responsiveness, crosstalk between protein kinase C and the adenylyl cyclase pathway is likely to have physiological consequences. Moreover, mGluRs themselves block the afterhyperpolarization, so the observed interference with the β-adrenergic response constitutes a hierarchical relationship in which mGluRs are dominant over β-adrenergic receptors.
KW - Afterhyperpolarization
KW - CA1
KW - Hierarchy
KW - Metabotropic glutamate receptor
KW - cAMP-Dependent protein kinase
KW - β-Adrenergic receptor
UR - http://www.scopus.com/inward/record.url?scp=0032513131&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(98)00131-1
DO - 10.1016/S0304-3940(98)00131-1
M3 - Article
C2 - 9572595
AN - SCOPUS:0032513131
SN - 0304-3940
VL - 244
SP - 101
EP - 105
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -