Metabotropic glutamate receptors limit adenylyl cyclase-mediated effects in rat hippocampus via protein kinase C

Rabin Nouranifar, Robert D. Blitzer, Tony Wong, Emmanuel Landau

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Glutamate receptors of the metabotropic type (mGluRs) activate protein kinase C in hippocampus, but few physiological functions of this pathway are known. The present data show that mGluRs utilize protein kinase C to inhibit another second messenger system, the adenylyl cyclase pathway, in neurons of the CA1 area of hippocampus. Activation of mGluRs prevented β-adrenergic receptors, which couple to adenylyl cyclase, from blocking the slow Ca2+- dependent afterhyperpolarization (AHP). Since the afterhyperpolarization modulates neuronal responsiveness, crosstalk between protein kinase C and the adenylyl cyclase pathway is likely to have physiological consequences. Moreover, mGluRs themselves block the afterhyperpolarization, so the observed interference with the β-adrenergic response constitutes a hierarchical relationship in which mGluRs are dominant over β-adrenergic receptors.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalNeuroscience Letters
Volume244
Issue number2
DOIs
StatePublished - 13 Mar 1998

Keywords

  • Afterhyperpolarization
  • CA1
  • Hierarchy
  • Metabotropic glutamate receptor
  • cAMP-Dependent protein kinase
  • β-Adrenergic receptor

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