TY - JOUR
T1 - Metabolism of [I-14C]lignoceric acid in the rat
AU - Gatt, S.
N1 - Funding Information:
This work was supported in part by grants from the National Institute for Neurological Diseases and Blindness, U.S. Public Health Service, Grant No. B-2967, and the Hadassah-Medical School Joint Committee.
PY - 1963
Y1 - 1963
N2 - [I-14C]Lignoceric (tetracosanoic) acid was synthesized and administered to rats. Following intravenous injection, the fatty acid accumulated in the liver, was slowly oxidized to 14CO2 and incorporated into sphingolipids, cholesterol esters and glycerides; a large portion of the administered acid was found as free fatty acid for periods of 24 h or more. After intracerebral administration to young rats, lignoceric acid was incorporated into the brain sphingolipids and glycerides. Incorporation of tritiated water, [I-14C]acetic and [I-14C]palmitic acids under similar conditions was also studied. The relative specific activities of the sphingomyelins, cerebrosides and ceramides are discussed in the light of currently available theories concerning synthesis of the sphingolipids.
AB - [I-14C]Lignoceric (tetracosanoic) acid was synthesized and administered to rats. Following intravenous injection, the fatty acid accumulated in the liver, was slowly oxidized to 14CO2 and incorporated into sphingolipids, cholesterol esters and glycerides; a large portion of the administered acid was found as free fatty acid for periods of 24 h or more. After intracerebral administration to young rats, lignoceric acid was incorporated into the brain sphingolipids and glycerides. Incorporation of tritiated water, [I-14C]acetic and [I-14C]palmitic acids under similar conditions was also studied. The relative specific activities of the sphingomyelins, cerebrosides and ceramides are discussed in the light of currently available theories concerning synthesis of the sphingolipids.
UR - https://www.scopus.com/pages/publications/50549210584
U2 - 10.1016/0006-3002(63)90766-2
DO - 10.1016/0006-3002(63)90766-2
M3 - Article
C2 - 14067610
AN - SCOPUS:50549210584
SN - 0006-3002
VL - 70
SP - 370
EP - 380
JO - BBA - Biochimica et Biophysica Acta
JF - BBA - Biochimica et Biophysica Acta
IS - C
ER -