Metabolism of adrenosterone

H. Leon Bradlow; David K. Fukushima; Kazunori Kozuma; Barnett Zumoff; Leon Hellman; T. F. Gallagher

doi:10.1016/0039-128X(67)90050-5

Metabolism of adrenosterone

H. Leon Bradlow, David K. Fukushima, Kazunori Kozuma, Barnett Zumoff, Leon Hellman, T. F. Gallagher

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Abstract

The metabolism of simultaneously administered adrenosterone-1,2-³H and 11β-hydroxy-Δ⁴-androstene-3,17-dione-4-¹⁴C has been studied in a normal and a hypothyroid subject. Conversion to the metabolites from either hormone was essentially alike demonstrating ready interconversion of the 11β-hydroxy and 11-keto groups of the administered hormones. Following a large dose of adrenosterone to a hypothyroid subject 3α-hydroxy-Δ⁴-and-rostene-11, 17-dione and its reaction product with urea, 3α-ureido-Δ⁴-and-rostene-11, 17-dione were isolated and characterized.

Original language	English
Pages (from-to)	233-244
Number of pages	12
Journal	Steroids
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0039-128X(67)90050-5
State	Published - Sep 1967
Externally published	Yes

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@article{780c85545d4043519a09748959a7d717,

title = "Metabolism of adrenosterone",

abstract = "The metabolism of simultaneously administered adrenosterone-1,2-3H and 11β-hydroxy-Δ4-androstene-3,17-dione-4-14C has been studied in a normal and a hypothyroid subject. Conversion to the metabolites from either hormone was essentially alike demonstrating ready interconversion of the 11β-hydroxy and 11-keto groups of the administered hormones. Following a large dose of adrenosterone to a hypothyroid subject 3α-hydroxy-Δ4-and-rostene-11, 17-dione and its reaction product with urea, 3α-ureido-Δ4-and-rostene-11, 17-dione were isolated and characterized.",

author = "Bradlow, {H. Leon} and Fukushima, {David K.} and Kazunori Kozuma and Barnett Zumoff and Leon Hellman and Gallagher, {T. F.}",

year = "1967",

month = sep,

doi = "10.1016/0039-128X(67)90050-5",

language = "English",

volume = "10",

pages = "233--244",

journal = "Steroids",

issn = "0039-128X",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Metabolism of adrenosterone

AU - Bradlow, H. Leon

AU - Fukushima, David K.

AU - Kozuma, Kazunori

AU - Zumoff, Barnett

AU - Hellman, Leon

AU - Gallagher, T. F.

PY - 1967/9

Y1 - 1967/9

N2 - The metabolism of simultaneously administered adrenosterone-1,2-3H and 11β-hydroxy-Δ4-androstene-3,17-dione-4-14C has been studied in a normal and a hypothyroid subject. Conversion to the metabolites from either hormone was essentially alike demonstrating ready interconversion of the 11β-hydroxy and 11-keto groups of the administered hormones. Following a large dose of adrenosterone to a hypothyroid subject 3α-hydroxy-Δ4-and-rostene-11, 17-dione and its reaction product with urea, 3α-ureido-Δ4-and-rostene-11, 17-dione were isolated and characterized.

AB - The metabolism of simultaneously administered adrenosterone-1,2-3H and 11β-hydroxy-Δ4-androstene-3,17-dione-4-14C has been studied in a normal and a hypothyroid subject. Conversion to the metabolites from either hormone was essentially alike demonstrating ready interconversion of the 11β-hydroxy and 11-keto groups of the administered hormones. Following a large dose of adrenosterone to a hypothyroid subject 3α-hydroxy-Δ4-and-rostene-11, 17-dione and its reaction product with urea, 3α-ureido-Δ4-and-rostene-11, 17-dione were isolated and characterized.

UR - http://www.scopus.com/inward/record.url?scp=0014123728&partnerID=8YFLogxK

U2 - 10.1016/0039-128X(67)90050-5

DO - 10.1016/0039-128X(67)90050-5

M3 - Article

C2 - 6057562

AN - SCOPUS:0014123728

SN - 0039-128X

VL - 10

SP - 233

EP - 244

JO - Steroids

JF - Steroids

IS - 3

ER -

Metabolism of adrenosterone

Abstract

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