TY - JOUR
T1 - Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition
AU - Lieber, C. S.
AU - Baraona, E.
AU - Leo, M. A.
AU - Garro, A.
N1 - Funding Information:
Ethanol is readily absorbed from the gastrointestinal tract. Only 2-10% of that absorbed is This work was supported by Department of Health and Human Services Grants AA03508, DK32810 and the Veterans Administration.
PY - 1987/11
Y1 - 1987/11
N2 - Different pathways of alcohol metabolism, the alcohol dehydrogenase pathway, the microsomal ethanol-oxidizing system and the catalase pathway are discussed. Alcohol consumption leads to accelerated ethanol metabolism by different mechanisms including an increased microsomal function. Microsomal induction leads to interactions of ethanol with drugs, hepatotoxic agents, steroids, vitamins and to an increased activation of mutagens/carcinogens. A number of ethanol-related complications may be explained by the production of its first metabolite, acetaldehyde, such as alterations of mitochondria, increased lipid peroxidation and microtubular alterations with its adverse effects on various cellular activities, including disturbances of cell division. Nutritional factors in alcoholics such as malnutrition are discussed especially with respect to its possible relation to cancer.
AB - Different pathways of alcohol metabolism, the alcohol dehydrogenase pathway, the microsomal ethanol-oxidizing system and the catalase pathway are discussed. Alcohol consumption leads to accelerated ethanol metabolism by different mechanisms including an increased microsomal function. Microsomal induction leads to interactions of ethanol with drugs, hepatotoxic agents, steroids, vitamins and to an increased activation of mutagens/carcinogens. A number of ethanol-related complications may be explained by the production of its first metabolite, acetaldehyde, such as alterations of mitochondria, increased lipid peroxidation and microtubular alterations with its adverse effects on various cellular activities, including disturbances of cell division. Nutritional factors in alcoholics such as malnutrition are discussed especially with respect to its possible relation to cancer.
KW - Alcohol dehydrogenase pathway
KW - Carcinogens
KW - Catalase pathway
KW - Drugs
KW - Ethanol, metabolism, metabolic effects
KW - Microsomal oxidizing system
KW - Nutrition
UR - http://www.scopus.com/inward/record.url?scp=0023272762&partnerID=8YFLogxK
U2 - 10.1016/0165-1110(87)90004-2
DO - 10.1016/0165-1110(87)90004-2
M3 - Article
C2 - 3313028
AN - SCOPUS:0023272762
SN - 0165-1110
VL - 186
SP - 201
EP - 233
JO - Mutation Research/Reviews in Genetic Toxicology
JF - Mutation Research/Reviews in Genetic Toxicology
IS - 3
ER -