Metabolic Syndrome and Type 2 Diabetes: Can We Stop the Weight Gain with Diabetes?

Denise Joffe, Robert T. Yanagisawa

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Many patients with type 2 diabetes also have the metabolic syndrome with its cardinal features of central adiposity, insulin resistance, dyslipidemia, and hypertension. Although there is strong evidence for the importance of tight glycemic control in minimizing the microvascular complications of diabetes, many of the current therapies used for optimizing glycemic control also cause weight gain. With this treatment-induced weight gain, there is a risk of worsening the patient's insulin resistance. Physicians need to be aware of this vicious cycle in their overweight type 2 diabetic patients. This article reviews the strategies currently available to achieve glycemic control while at the same time minimizing weight gain and the associated complications.

Original languageEnglish
Pages (from-to)1107-1123
Number of pages17
JournalMedical Clinics of North America
Issue number6
StatePublished - Nov 2007


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