Metabolic anticipation in Mycobacterium tuberculosis

Hyungjin Eoh, Zhe Wang, Emilie Layre, Poonam Rath, Roxanne Morris, D. Branch Moody, Kyu Y. Rhee

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Humans serve as both host and reservoir for Mycobacterium tuberculosis, making tuberculosis a theoretically eradicable disease. How M. tuberculosis alternates between host-imposed quiescence and sporadic bouts of replication to complete its life cycle, however, remains unknown. Here, we identify a metabolic adaptation that is triggered upon entry into hypoxia-induced quiescence but facilitates subsequent cell cycle re-entry. Catabolic remodelling of the cell surface trehalose mycolates of M. tuberculosis specifically generates metabolic intermediates reserved for re-initiation of peptidoglycan biosynthesis. These adaptations reveal a metabolic network with the regulatory capacity to mount an anticipatory response.

Original languageEnglish
JournalNature Microbiology
Volume2
DOIs
StatePublished - 22 May 2017
Externally publishedYes

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