Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Doretta Caramaschi; Alexander Neumann; Andres Cardenas; Gwen Tindula; Silvia Alemany; Lea Zillich; Giancarlo Pesce; Jari M.T. Lahti; Alexandra Havdahl; Rosa Mulder; Janine F. Felix; Henning Tiemeier; Lea Sirignano; Josef Frank; Stephanie H. Witt; Marcella Rietschel; Michael Deuschle; Karen Huen; Brenda Eskenazi; Tabea Sarah Send; Muriel Ferrer; Maria Gilles; Maria de Agostini; Nour Baïz; Sheryl L. Rifas-Shiman; Tuomas Kvist; Darina Czamara; Samuli T. Tuominen; Caroline L. Relton; Dheeraj Rai; Stephanie J. London; Katri Räikkönen; Nina Holland; Isabella Annesi-Maesano; Fabian Streit; Marie France Hivert; Emily Oken; Jordi Sunyer; Charlotte A.M. Cecil; Gemma Sharp

doi:10.1038/s41380-022-01441-w

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Doretta Caramaschi, Alexander Neumann, Andres Cardenas, Gwen Tindula, Silvia Alemany, Lea Zillich, Giancarlo Pesce, Jari M.T. Lahti, Alexandra Havdahl, Rosa Mulder, Janine F. Felix, Henning Tiemeier, Lea Sirignano, Josef Frank, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Karen Huen, Brenda Eskenazi, Tabea Sarah SendMuriel Ferrer, Maria Gilles, Maria de Agostini, Nour Baïz, Sheryl L. Rifas-Shiman, Tuomas Kvist, Darina Czamara, Samuli T. Tuominen, Caroline L. Relton, Dheeraj Rai, Stephanie J. London, Katri Räikkönen, Nina Holland, Isabella Annesi-Maesano, Fabian Streit, Marie France Hivert, Emily Oken, Jordi Sunyer, Charlotte A.M. Cecil, Gemma Sharp

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.

Original language	English
Pages (from-to)	2126-2135
Number of pages	10
Journal	Molecular Psychiatry
Volume	27
Issue number	4
DOIs	https://doi.org/10.1038/s41380-022-01441-w
State	Published - Apr 2022
Externally published	Yes

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Caramaschi, D., Neumann, A., Cardenas, A., Tindula, G., Alemany, S., Zillich, L., Pesce, G., Lahti, J. M. T., Havdahl, A., Mulder, R., Felix, J. F., Tiemeier, H., Sirignano, L., Frank, J., Witt, S. H., Rietschel, M., Deuschle, M., Huen, K., Eskenazi, B., ... Sharp, G. (2022). Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Molecular Psychiatry, 27(4), 2126-2135. https://doi.org/10.1038/s41380-022-01441-w

@article{f8dbee416bad439f9b90b16e47876b49,

title = "Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills",

abstract = "Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.",

author = "Doretta Caramaschi and Alexander Neumann and Andres Cardenas and Gwen Tindula and Silvia Alemany and Lea Zillich and Giancarlo Pesce and Lahti, {Jari M.T.} and Alexandra Havdahl and Rosa Mulder and Felix, {Janine F.} and Henning Tiemeier and Lea Sirignano and Josef Frank and Witt, {Stephanie H.} and Marcella Rietschel and Michael Deuschle and Karen Huen and Brenda Eskenazi and Send, {Tabea Sarah} and Muriel Ferrer and Maria Gilles and {de Agostini}, Maria and Nour Ba{\"i}z and Rifas-Shiman, {Sheryl L.} and Tuomas Kvist and Darina Czamara and Tuominen, {Samuli T.} and Relton, {Caroline L.} and Dheeraj Rai and London, {Stephanie J.} and Katri R{\"a}ikk{\"o}nen and Nina Holland and Isabella Annesi-Maesano and Fabian Streit and Hivert, {Marie France} and Emily Oken and Jordi Sunyer and Cecil, {Charlotte A.M.} and Gemma Sharp",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = apr,

doi = "10.1038/s41380-022-01441-w",

language = "English",

volume = "27",

pages = "2126--2135",

journal = "Molecular Psychiatry",

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Caramaschi, D, Neumann, A, Cardenas, A, Tindula, G, Alemany, S, Zillich, L, Pesce, G, Lahti, JMT, Havdahl, A, Mulder, R, Felix, JF, Tiemeier, H, Sirignano, L, Frank, J, Witt, SH, Rietschel, M, Deuschle, M, Huen, K, Eskenazi, B, Send, TS, Ferrer, M, Gilles, M, de Agostini, M, Baïz, N, Rifas-Shiman, SL, Kvist, T, Czamara, D, Tuominen, ST, Relton, CL, Rai, D, London, SJ, Räikkönen, K, Holland, N, Annesi-Maesano, I, Streit, F, Hivert, MF, Oken, E, Sunyer, J, Cecil, CAM & Sharp, G 2022, 'Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills', Molecular Psychiatry, vol. 27, no. 4, pp. 2126-2135. https://doi.org/10.1038/s41380-022-01441-w

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AU - Caramaschi, Doretta

AU - Neumann, Alexander

AU - Cardenas, Andres

AU - Tindula, Gwen

AU - Alemany, Silvia

AU - Zillich, Lea

AU - Pesce, Giancarlo

AU - Lahti, Jari M.T.

AU - Havdahl, Alexandra

AU - Mulder, Rosa

AU - Felix, Janine F.

AU - Tiemeier, Henning

AU - Sirignano, Lea

AU - Frank, Josef

AU - Witt, Stephanie H.

AU - Rietschel, Marcella

AU - Deuschle, Michael

AU - Huen, Karen

AU - Eskenazi, Brenda

AU - Send, Tabea Sarah

AU - Ferrer, Muriel

AU - Gilles, Maria

AU - de Agostini, Maria

AU - Baïz, Nour

AU - Rifas-Shiman, Sheryl L.

AU - Kvist, Tuomas

AU - Czamara, Darina

AU - Tuominen, Samuli T.

AU - Relton, Caroline L.

AU - Rai, Dheeraj

AU - London, Stephanie J.

AU - Räikkönen, Katri

AU - Holland, Nina

AU - Annesi-Maesano, Isabella

AU - Streit, Fabian

AU - Hivert, Marie France

AU - Oken, Emily

AU - Sunyer, Jordi

AU - Cecil, Charlotte A.M.

AU - Sharp, Gemma

PY - 2022/4

Y1 - 2022/4

N2 - Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.

AB - Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.

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DO - 10.1038/s41380-022-01441-w

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AN - SCOPUS:85124517315

SN - 1359-4184

VL - 27

SP - 2126

EP - 2135

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 4

ER -

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Abstract

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