@article{c94d8843371246aeab5035c0c8fb13bd,
title = "Meta-analysis confirms the LCE3C-LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6",
abstract = "A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall=1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR=1.27 (1.16-1.34)) and Mongolian (OR=2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.",
author = "Eva Riveira-Munoz and He, \{Su Min\} and Georgia Escaram{\'i}s and Stuart, \{Philip E.\} and Ulrike H{\"u}ffmeier and Catherine Lee and Brian Kirby and Akira Oka and Emiliano Giardina and Wilson Liao and Judith Bergboer and Kati Kainu and \{De Cid\}, Rafael and Batmunkh Munkhbat and Zeeuwen, \{Patrick L.J.M.\} and Armour, \{John A.L.\} and Annie Poon and Tomotaka Mabuchi and Akira Ozawa and Agnieszka Zawirska and Burden, \{A. David\} and Barker, \{Jonathan N.\} and Francesca Capon and Heiko Traupe and Sun, \{Liang Dan\} and Yong Cui and Yin, \{Xian Yong\} and Gang Chen and Lim, \{Henry W.\} and Nair, \{Rajan P.\} and Voorhees, \{John J.\} and Trilokraj Tejasvi and Ram{\'o}n Pujol and Namid Munkhtuvshin and Judith Fischer and Juha Kere and Joost Schalkwijk and Anne Bowcock and Kwok, \{Pui Yan\} and Giuseppe Novelli and Hidetoshi Inoko and Ryan, \{Anthony W.\} and Trembath, \{Richard C.\} and Andr{\'e} Reis and Zhang, \{Xue Jun\} and Elder, \{James T.\} and Xavier Estivill",
note = "Funding Information: We thank all the psoriasis patients and their families for their participation in this study. We acknowledge our collaborating partners who contributed to the meta-analysis (see Supplementary Note online). Funding for this study was provided by: the Spanish Ministry of Science and Innovation (grant SAF 2008-00357) and the “Generalitat de Catalunya” Departments of Health and Universities and Innovation (to ER-M, GE, and XE); the General Program of National Natural Science Foundation of China (30771196, 30800990) (to X-JZ); the Medical Research Council grant G0000934; and the Wellcome Trust grant 068545/Z/02. We also acknowledge support from the UK Medical Research Council (to RCT and JNB, grant G0601387) and the British Skin Foundation (to FC, grant 1006); Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Tokai University School of Medicine Research Aid (to AO, TM, AO, and HI); and ADIPSO (Italian Association for the Defence of Psoriasis Patients) (to EG and GN). The Interdisciplinary Centre for Clinical Research (IZKF B32/A8) of University of Erlangen-Nuremberg supported UH, HT, and AR. WL is supported by a grant of the Dermatology Foundation; JK and KK were supported by the Academy of Finland and Sigrid Juselius Foundation. We also acknowledge funding from Centre National de G{\'e}notypage (to RdC and JF). Research for the US-Michigan study was supported by grants R01AR42742, R01AR050511, and R01AR054966 from the National Institutes of Health, and by the Ann Arbor Veteran Affairs Hospital. AMB is supported by the NIH grant R01 AR050266. AWR acknowledges funding from the Irish Health Research Board and Science Foundation, Ireland. ",
year = "2011",
month = may,
doi = "10.1038/jid.2010.350",
language = "English",
volume = "131",
pages = "1105--1109",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Elsevier B.V.",
number = "5",
}