Meta-analysis confirms the LCE3C-LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6

Eva Riveira-Munoz, Su Min He, Georgia Escaramís, Philip E. Stuart, Ulrike Hüffmeier, Catherine Lee, Brian Kirby, Akira Oka, Emiliano Giardina, Wilson Liao, Judith Bergboer, Kati Kainu, Rafael De Cid, Batmunkh Munkhbat, Patrick L.J.M. Zeeuwen, John A.L. Armour, Annie Poon, Tomotaka Mabuchi, Akira Ozawa, Agnieszka ZawirskaA. David Burden, Jonathan N. Barker, Francesca Capon, Heiko Traupe, Liang Dan Sun, Yong Cui, Xian Yong Yin, Gang Chen, Henry W. Lim, Rajan P. Nair, John J. Voorhees, Trilokraj Tejasvi, Ramón Pujol, Namid Munkhtuvshin, Judith Fischer, Juha Kere, Joost Schalkwijk, Anne Bowcock, Pui Yan Kwok, Giuseppe Novelli, Hidetoshi Inoko, Anthony W. Ryan, Richard C. Trembath, André Reis, Xue Jun Zhang, James T. Elder, Xavier Estivill

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83 Scopus citations


A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall=1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR=1.27 (1.16-1.34)) and Mongolian (OR=2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

Original languageEnglish
Pages (from-to)1105-1109
Number of pages5
JournalJournal of Investigative Dermatology
Issue number5
StatePublished - May 2011
Externally publishedYes


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