@article{77a7935bce6441e6a075c50d6b1a0d72,
title = "Mesenchymal dysplasia: A recessive mutation on chromosome 13 of the mouse",
abstract = "Mesenchymal dysplasia (mes) is a new autosomal recessive mouse mutation that alters normal growth of mesenchyme-derived tissues and provides a new mouse model for studying connective tissue development and defects. Mutants are characterized by preaxial polydactyly of all four feet, a shortened face, wide set eyes, domed head, and a shortened kinky tail. Multiple skeletal defects are seen in alizarin-stained specimens. Histologically, areas of mineralization are found in tendons. Mutants also have increased musculature in the shoulders and hips and decreased peritoneal fat. Salivary glands, testes, and kidneys are smaller than in littermates. Mesenchymal dysplasia has been mapped to mouse chromosome (Chr) 13. These mapping crosses also confirmed that the Purkinje cell degeneration (pcd) mutation is on Chr 13.",
author = "Sweet, {H. O.} and Bronson, {R. T.} and Donahue, {L. R.} and Davisson, {M. T.}",
note = "Funding Information: From The Jackson Laboratory, 600 Main St., Bar Harbor, Maine 04609-1500 (Sweet, Bronson, Donahue, and Davisson) and Tufts University, School of Veterinary Medicine, Boston, Massachusetts (Bronson). We dedicate this paper to Dr. Margaret C. Green. This work was supported by grants BIR 89-15728 from the National Science Foundation, P40 RR01183 and Cancer Core Center grant CA34196 from the National Institutes of Health, and a gift from the Eleanor Naylor Dana Charitable Trust. The antlserom (UB2-495) to IGF-1 was a gift from the National Hormone and Pituitary Program, National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Child Health and Human Development, and the U.S. Department of Agriculture. We thank Belinda Harris, Ann Hlgglns, and Prlscllla Jewett for hlstologlcal preparations, W. a Beamer lor helpful discussions, Unda Nelesld for manuscript preparation, and Drs. Margaret C. Green and Kevin Flurkey for critical review of the manuscript. Address reprint requests to H. 0. Sweet at the address above.",
year = "1996",
doi = "10.1093/oxfordjournals.jhered.a022981",
language = "English",
volume = "87",
pages = "87--95",
journal = "Journal of Heredity",
issn = "0022-1503",
publisher = "Oxford University Press",
number = "2",
}