Mental Stress and the Induction of Silent Myocardial Ischemia in Patients with Coronary Artery Disease

Alan Rozanski, C. Noel Bairey, David S. Krantz, John Friedman, Kenneth J. Resser, Marie Morell, Sally Hilton-Chalfen, Lisa Hestrin, James Bietendorf, Daniel S. Berman

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To assess the causal relation between acute mental stress and myocardial ischemia, we evaluated cardiac function in selected patients during a series of mental tasks (arithmetic, the Stroop color–word task, simulated public speaking, and reading) and compared the responses with those induced by exercise. Thirty-nine patients with coronary artery disease and 12 controls were studied by radionuclide ventriculography. Of the patients with coronary artery disease, 23 (59 percent) had wall-motion abnormalities during periods of mental stress and 14 (36 percent) had a fall in ejection fraction of more than 5 percentage points. Ischemia induced by mental stress was symptomatically “silent” in 19 of the 23 patients with wall-motion abnormalities (83 percent) and occurred at lower heart rates than exercise-induced ischemia (P<0.05). In contrast, we observed comparable elevations in arterial pressure during ischemia induced by mental stress and ischemia induced by exercise. A personally relevant, emotionally arousing speaking task induced more frequent and greater regional wall-motion abnormalities than did less specific cognitive tasks causing mental stress (P<0.05). The magnitude of cardiac dysfunction induced by the speaking task was similar to that induced by exercise. Personally relevant mental stress may be an important precipitant of myocardial ischemia — often silent — in patients with coronary artery disease. Further examination of the pathophysiologic mechanisms responsible for myocardial ischemia induced by mental stress could have important implications for the treatment of transient myocardial ischemia. (N Engl J Med 1988; 318:1005–12.)

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalNew England Journal of Medicine
Issue number16
StatePublished - 21 Apr 1988
Externally publishedYes


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