Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

Claudia Massarotti; Elvira Sbragia; Giacomo Boffa; Caterina Vercelli; Giovanni Bosco Zimatore; Salvatore Cottone; Jessica Frau; Annamaria Raiola; Riccardo Varaldo; Gianluigi Mancardi; Matilde Inglese; Paola Anserini

doi:10.1177/13524585211000616

Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

Claudia Massarotti, Elvira Sbragia, Giacomo Boffa, Caterina Vercelli, Giovanni Bosco Zimatore, Salvatore Cottone, Jessica Frau, Annamaria Raiola, Riccardo Varaldo, Gianluigi Mancardi, Matilde Inglese, Paola Anserini

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15 Scopus citations

Abstract

Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens’ intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.

Original language	English
Pages (from-to)	2103-2107
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	27
Issue number	13
DOIs	https://doi.org/10.1177/13524585211000616
State	Published - Nov 2021
Externally published	Yes

Keywords

Aggressive multiple sclerosis
amenorrhea
autologous hematopoietic stem cell transplantation
fertility
menstrual cycle

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Massarotti, C., Sbragia, E., Boffa, G., Vercelli, C., Zimatore, G. B., Cottone, S., Frau, J., Raiola, A., Varaldo, R., Mancardi, G., Inglese, M., & Anserini, P. (2021). Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis. Multiple Sclerosis Journal, 27(13), 2103-2107. https://doi.org/10.1177/13524585211000616

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title = "Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis",

abstract = "Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens{\textquoteright} intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.",

keywords = "Aggressive multiple sclerosis, amenorrhea, autologous hematopoietic stem cell transplantation, fertility, menstrual cycle",

author = "Claudia Massarotti and Elvira Sbragia and Giacomo Boffa and Caterina Vercelli and Zimatore, {Giovanni Bosco} and Salvatore Cottone and Jessica Frau and Annamaria Raiola and Riccardo Varaldo and Gianluigi Mancardi and Matilde Inglese and Paola Anserini",

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year = "2021",

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Massarotti, C, Sbragia, E, Boffa, G, Vercelli, C, Zimatore, GB, Cottone, S, Frau, J, Raiola, A, Varaldo, R, Mancardi, G, Inglese, M & Anserini, P 2021, 'Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis', Multiple Sclerosis Journal, vol. 27, no. 13, pp. 2103-2107. https://doi.org/10.1177/13524585211000616

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T1 - Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

AU - Massarotti, Claudia

AU - Sbragia, Elvira

AU - Boffa, Giacomo

AU - Vercelli, Caterina

AU - Zimatore, Giovanni Bosco

AU - Cottone, Salvatore

AU - Frau, Jessica

AU - Raiola, Annamaria

AU - Varaldo, Riccardo

AU - Mancardi, Gianluigi

AU - Inglese, Matilde

AU - Anserini, Paola

N1 - Publisher Copyright: © The Author(s), 2021.

PY - 2021/11

Y1 - 2021/11

N2 - Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens’ intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.

AB - Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens’ intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.

KW - Aggressive multiple sclerosis

KW - amenorrhea

KW - autologous hematopoietic stem cell transplantation

KW - fertility

KW - menstrual cycle

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Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

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Keywords

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