TY - JOUR
T1 - Meningeal Carcinomatosis
AU - Theodore, William H.
AU - Gendelman, Seymour
PY - 1981/11
Y1 - 1981/11
N2 - We reviewed 33 cases of meningeal carcinomatosis seen at the Mount Sinai Hospital, New York, from 1970 through 1979. The major sources of meningeal disease were carcinoma of the breast (21 cases), carcinoma of the lung (five), and malignant melanoma (five). Seventy-eight percent of the patients had widespread metastases at the time of neurologic diagnosis. A combination of radiotherapy and intrathecal administration of methotrexate was the most successful treatment, and 14 of 22 treated patients showed at least symptomatic improvement; however, mean survival in the most improved group was still less than six months.
AB - We reviewed 33 cases of meningeal carcinomatosis seen at the Mount Sinai Hospital, New York, from 1970 through 1979. The major sources of meningeal disease were carcinoma of the breast (21 cases), carcinoma of the lung (five), and malignant melanoma (five). Seventy-eight percent of the patients had widespread metastases at the time of neurologic diagnosis. A combination of radiotherapy and intrathecal administration of methotrexate was the most successful treatment, and 14 of 22 treated patients showed at least symptomatic improvement; however, mean survival in the most improved group was still less than six months.
UR - http://www.scopus.com/inward/record.url?scp=0019466463&partnerID=8YFLogxK
U2 - 10.1001/archneur.1981.00510110056008
DO - 10.1001/archneur.1981.00510110056008
M3 - Article
C2 - 6975612
AN - SCOPUS:0019466463
SN - 0003-9942
VL - 38
SP - 696
EP - 699
JO - Archives of Neurology
JF - Archives of Neurology
IS - 11
ER -