@article{40e5e6ae2fb045e4a068c05e6f7ee3aa,
title = "Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics",
abstract = "Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila Abl. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility.",
author = "Gertler, {Frank B.} and Kirsten Niebuhr and Matthias Reinhard and J{\"u}rgen Wehland and Philippe Soriano",
note = "Funding Information: Correspondence should be addressed to F. B. G. We are deeply indebted to Michael Hoffmann for support during the initial phase of this work. Our thanks go to Mary Beckerle, Trinad Chakraborty, Jonathan Cooper, Frank Ebel, Sal Fuerstenberg, Jeff Hildebrand, Brian Howell, Akira Imamoto, Sheila Thomas, and Ulrich Walter for their support and valuable discussions. We thank Steve Tapscott and Anne Vojtek for critical reading of the manuscrip, Mary Beckerle for anti-zyxin antibodies, Stephan Feller for SH3 fusion constructs, Birgit Gerstel and Josef Wissing for recombinant ActA, Tom Jessell for neurofilament antibody, and Susanne Talay for purified GST and GST-antibodies. We are grateful to Ronald Frank for help with the peptide synthesis, Paul Goodwin for assistance on microscopy, and Brian Howell for P19 cell culture. Use of the image analysis and biotechnology facilities was made possible by core grants to the FHCRC. F. B. G. is a Leukemia Society of America Special Fellow (#3337-95). M. R. is supported by the Deutsche Forschungsgemeinschaft (SFB 176/A21). This work was supported by grants from the National Institutes of Health and Markey Molecular Medicine Center to P. S. ",
year = "1996",
month = oct,
day = "18",
doi = "10.1016/S0092-8674(00)81341-0",
language = "English",
volume = "87",
pages = "227--239",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}