Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics

Frank B. Gertler, Kirsten Niebuhr, Matthias Reinhard, Jürgen Wehland, Philippe Soriano

Research output: Contribution to journalArticlepeer-review

561 Scopus citations

Abstract

Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila Abl. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility.

Original languageEnglish
Pages (from-to)227-239
Number of pages13
JournalCell
Volume87
Issue number2
DOIs
StatePublished - 18 Oct 1996
Externally publishedYes

Fingerprint

Dive into the research topics of 'Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics'. Together they form a unique fingerprint.

Cite this