Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection

Yu Kato, Nathaniel I. Bloom, Peifang Sun, Corey A. Balinsky, Qi Qiu, Ying Cheng, Vihasi Jani, Megan A. Schilling, Carl W. Goforth, Dawn L. Weir, Irene Ramos, Stuart C. Sealfon, Andrew G. Letizia, Shane Crotty

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background. The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood. Methods. We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection. Results. Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells. Conclusions. Among young adults, asymptomatic SARSCoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalJournal of Infectious Diseases
Issue number1
StatePublished - 1 Jan 2023


  • COVID-19 immunity
  • SARS-CoV-2
  • adaptive immune response
  • asymptomatic infection
  • memory B cells
  • mild infection


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