Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection

Yu Kato; Nathaniel I. Bloom; Peifang Sun; Corey A. Balinsky; Qi Qiu; Ying Cheng; Vihasi Jani; Megan A. Schilling; Carl W. Goforth; Dawn L. Weir; Irene Ramos; Stuart C. Sealfon; Andrew G. Letizia; Shane Crotty

doi:10.1093/infdis/jiac319

Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection

Yu Kato, Nathaniel I. Bloom, Peifang Sun, Corey A. Balinsky, Qi Qiu, Ying Cheng, Vihasi Jani, Megan A. Schilling, Carl W. Goforth, Dawn L. Weir, Irene Ramos, Stuart C. Sealfon, Andrew G. Letizia, Shane Crotty

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background. The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood. Methods. We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection. Results. Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells. Conclusions. Among young adults, asymptomatic SARSCoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.

Original language	English
Pages (from-to)	18-22
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	227
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiac319
State	Published - 1 Jan 2023

Keywords

COVID-19 immunity
SARS-CoV-2
adaptive immune response
asymptomatic infection
memory B cells
mild infection

Access to Document

10.1093/infdis/jiac319

Cite this

@article{1edac9178f1a4d9983c564a2aee2cd10,

title = "Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection",

abstract = "Background. The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood. Methods. We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection. Results. Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells. Conclusions. Among young adults, asymptomatic SARSCoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.",

keywords = "COVID-19 immunity, SARS-CoV-2, adaptive immune response, asymptomatic infection, memory B cells, mild infection",

author = "Yu Kato and Bloom, {Nathaniel I.} and Peifang Sun and Balinsky, {Corey A.} and Qi Qiu and Ying Cheng and Vihasi Jani and Schilling, {Megan A.} and Goforth, {Carl W.} and Weir, {Dawn L.} and Irene Ramos and Sealfon, {Stuart C.} and Letizia, {Andrew G.} and Shane Crotty",

year = "2023",

month = jan,

day = "1",

doi = "10.1093/infdis/jiac319",

language = "English",

volume = "227",

pages = "18--22",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection

AU - Kato, Yu

AU - Bloom, Nathaniel I.

AU - Sun, Peifang

AU - Balinsky, Corey A.

AU - Qiu, Qi

AU - Cheng, Ying

AU - Jani, Vihasi

AU - Schilling, Megan A.

AU - Goforth, Carl W.

AU - Weir, Dawn L.

AU - Ramos, Irene

AU - Sealfon, Stuart C.

AU - Letizia, Andrew G.

AU - Crotty, Shane

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Background. The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood. Methods. We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection. Results. Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells. Conclusions. Among young adults, asymptomatic SARSCoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.

AB - Background. The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood. Methods. We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection. Results. Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells. Conclusions. Among young adults, asymptomatic SARSCoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.

KW - COVID-19 immunity

KW - SARS-CoV-2

KW - adaptive immune response

KW - asymptomatic infection

KW - memory B cells

KW - mild infection

UR - http://www.scopus.com/inward/record.url?scp=85142418641&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiac319

DO - 10.1093/infdis/jiac319

M3 - Article

C2 - 35892131

AN - SCOPUS:85142418641

SN - 0022-1899

VL - 227

SP - 18

EP - 22

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 1

ER -

Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection

Abstract

Keywords

Access to Document

Fingerprint

Cite this