Abstract
These studies suggest that random adversive stimuli in rats can lead to a reasonable model of depression and that the exposure to adverse stimuli in genetically susceptible animals leads to long-term CNS changes which are correlated with long-term behavioral changes. This model is a good screen for antidepressant drugs, and all active drugs tested appear to specifically down-regulate hippocampal beta receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 443-446 |
| Number of pages | 4 |
| Journal | Psychopharmacology Bulletin |
| Volume | 21 |
| Issue number | 3 |
| State | Published - 1985 |
| Externally published | Yes |