MEK and MAF in myeloma therapy

Relja Popovic, Jonathan D. Licht

Research output: Contribution to journalComment/debate

11 Scopus citations


Despite increased understanding of molecular pathogenesis of multiple myeloma and implementation of therapies such as bortezomib and thalidomide, only 10% of patients survive more than 10 years after diagnosis. Until recently, new therapies for myeloma have not been developed based on a detailed understanding of the molecular pathology of the disease. In this issue of Blood, Annunziata et al report a rationale for the use of mitogen-activated or extracellular signal-regulated protein kinase (MEK) inhibitors in the subset of myeloma patients expressing high levels of theMAF oncogene.

Original languageEnglish
Pages (from-to)2300-2302
Number of pages3
Issue number8
StatePublished - 24 Feb 2011
Externally publishedYes


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