Meeting the challenges of neuroimaging genetics

Greig I. de Zubicaray, Ming Chang Chiang, Katie L. McMahon, David W. Shattuck, Arthur W. Toga, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

As research encompassing neuroimaging and genetics gains momentum, extraordinary information will be uncovered on the genetic architecture of the human brain. However, there are significant challenges to be addressed first. Not the least of these challenges is to accomplish the sample size necessary to detect subtle genetic influences on the morphometry and function of the healthy brain. Aside from sample size, image acquisition and analysis methods need to be refined in order to ensure optimum sensitivity to genetic and complementary environmental influences. Then there is the vexing issue of interpreting the resulting data. We describe how researchers from the east coast of Australia and the west coast of America have embarked upon a collaboration to meet these challenges using data currently being collected from a large-scale twin study, and offer some opinions about future directions in the field.

Original languageEnglish
Pages (from-to)258-263
Number of pages6
JournalBrain Imaging and Behavior
Volume2
Issue number4
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • ACE modeling
  • Genetics
  • Heritability
  • High-angular resolution diffusion imaging (HARDI)
  • Neuroimaging

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