Medication persistence of HIV-infected drug users on directly administered antiretroviral therapy

Eileen C. Ing, Jason W. Bae, Duncan Smith Rohrberg Maru, Frederick L. Altice

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Patient and regimen persistence in HIV-infected drug users are largely unknown. We evaluated patterns of medication non-persistence among HIV-infected drug users enrolled in a prospective, 6-month randomized controlled trial of directly administered antiretroviral therapy (DAART). Medication-taking behavior was assessed via direct observation and MEMS data. Of 74 participants who initiated DAART, 59 (80%) subjects were non-persistent with medication for 3 or more consecutive days. Thirty-one participants (42%) had 2 or more episodes of non-persistence. Higher depressive symptoms were strongly associated with non-persistence episodes of ≥ 3 days (AOR: 17.4, P = 0.02) and ≥ 7 days AOR: 5.4, P = 0.04). High addiction severity (AOR 3.2, P = 0.03) was correlated with non-persistence ≥ 7 days, and injection drug use (AOR: 15.2, P = 0.02) with recurrence of non-persistence ≥ 3 days. Time to regimen change was shorter for NNRTI-based regimens compared to PI-based ones (HR: 3.0, P = 0.03). There was no significant association between patterns of patient non-persistence and virological outcomes.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalAIDS and Behavior
Volume17
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Addiction severity
  • Adherence
  • Depression
  • Directly administered antiretroviral therapy
  • HIV
  • Persistence
  • Substance abuse

Fingerprint

Dive into the research topics of 'Medication persistence of HIV-infected drug users on directly administered antiretroviral therapy'. Together they form a unique fingerprint.

Cite this