Medical Management of LPR

Justin Field, Deena Midani, Yellowlees Douglas, Michael S. Smith

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Laryngopharyngeal reflux (LPR) is a disorder that may cause a variety of symptoms, including dysphagia, chronic cough, postnasal drip, hoarseness, and fatigue. These symptoms stem from gastroesophageal reflux disease (GERD), which is far more widely studied and also offers multiple treatment modalities compared to the understudied LPR. These approaches prove particularly relevant for patients who have failed lifestyle modifications and include pharmacotherapy ranging from proton-pump inhibitors and histamine-2 receptor antagonists to GABAB agonists and neuromodulators. In addition, relatively new and minimally invasive endoscopic techniques for addressing LPR include transoral incisionless fundoplication, radiofrequency ablation of the lower esophageal sphincter, and anterior fundoplication, any of which may provide patients with relief from symptoms of LPR.

Original languageEnglish
Title of host publicationLaryngopharyngeal Reflux Disease
Subtitle of host publicationIntegrative Approaches
PublisherSpringer International Publishing
Number of pages15
ISBN (Electronic)9783030123185
ISBN (Print)9783030123178
StatePublished - 1 Jan 2019
Externally publishedYes


  • Endoscopic fundoplication
  • Gastroesophageal reflux disease
  • Laryngopharyngeal reflux
  • Neuromodulators
  • Prokinetics
  • Proton-pump inhibitors


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