Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

Marieke A. Stammes; Ji Hyun Lee; Lisette Meijer; Thibaut Naninck; Lara A. Doyle-Meyers; Alexander G. White; H. Jacob Borish; Amy L. Hartman; Xavier Alvarez; Shashank Ganatra; Deepak Kaushal; Rudolf P. Bohm; Roger le Grand; Charles A. Scanga; Jan A.M. Langermans; Ronald E. Bontrop; Courtney L. Finch; Jo Anne L. Flynn; Claudia Calcagno; Ian Crozier; Jens H. Kuhn

doi:10.1016/j.molmed.2021.12.001

Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

Marieke A. Stammes, Ji Hyun Lee, Lisette Meijer, Thibaut Naninck, Lara A. Doyle-Meyers, Alexander G. White, H. Jacob Borish, Amy L. Hartman, Xavier Alvarez, Shashank Ganatra, Deepak Kaushal, Rudolf P. Bohm, Roger le Grand, Charles A. Scanga, Jan A.M. Langermans, Ronald E. Bontrop, Courtney L. Finch, Jo Anne L. Flynn, Claudia Calcagno, Ian CrozierJens H. Kuhn

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Chest X-ray (CXR), computed tomography (CT), and positron emission tomography–computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.

Original language	English
Pages (from-to)	123-142
Number of pages	20
Journal	Trends in Molecular Medicine
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.molmed.2021.12.001
State	Published - Feb 2022
Externally published	Yes

Keywords

COVID-19
SARS-CoV-2
imaging
lung
non-human primate

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10.1016/j.molmed.2021.12.001

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Stammes, M. A., Lee, J. H., Meijer, L., Naninck, T., Doyle-Meyers, L. A., White, A. G., Borish, H. J., Hartman, A. L., Alvarez, X., Ganatra, S., Kaushal, D., Bohm, R. P., le Grand, R., Scanga, C. A., Langermans, J. A. M., Bontrop, R. E., Finch, C. L., Flynn, J. A. L., Calcagno, C., ... Kuhn, J. H. (2022). Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates. Trends in Molecular Medicine, 28(2), 123-142. https://doi.org/10.1016/j.molmed.2021.12.001

@article{53e154ebe05d4637a3711dbf0177fa06,

title = "Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates",

abstract = "Chest X-ray (CXR), computed tomography (CT), and positron emission tomography–computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.",

keywords = "COVID-19, SARS-CoV-2, imaging, lung, non-human primate",

author = "Stammes, {Marieke A.} and Lee, {Ji Hyun} and Lisette Meijer and Thibaut Naninck and Doyle-Meyers, {Lara A.} and White, {Alexander G.} and Borish, {H. Jacob} and Hartman, {Amy L.} and Xavier Alvarez and Shashank Ganatra and Deepak Kaushal and Bohm, {Rudolf P.} and {le Grand}, Roger and Scanga, {Charles A.} and Langermans, {Jan A.M.} and Bontrop, {Ronald E.} and Finch, {Courtney L.} and Flynn, {Jo Anne L.} and Claudia Calcagno and Ian Crozier and Kuhn, {Jens H.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2022",

month = feb,

doi = "10.1016/j.molmed.2021.12.001",

language = "English",

volume = "28",

pages = "123--142",

journal = "Trends in Molecular Medicine",

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Stammes, MA, Lee, JH, Meijer, L, Naninck, T, Doyle-Meyers, LA, White, AG, Borish, HJ, Hartman, AL, Alvarez, X, Ganatra, S, Kaushal, D, Bohm, RP, le Grand, R, Scanga, CA, Langermans, JAM, Bontrop, RE, Finch, CL, Flynn, JAL, Calcagno, C, Crozier, I & Kuhn, JH 2022, 'Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates', Trends in Molecular Medicine, vol. 28, no. 2, pp. 123-142. https://doi.org/10.1016/j.molmed.2021.12.001

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T1 - Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

AU - Stammes, Marieke A.

AU - Lee, Ji Hyun

AU - Meijer, Lisette

AU - Naninck, Thibaut

AU - Doyle-Meyers, Lara A.

AU - White, Alexander G.

AU - Borish, H. Jacob

AU - Hartman, Amy L.

AU - Alvarez, Xavier

AU - Ganatra, Shashank

AU - Kaushal, Deepak

AU - Bohm, Rudolf P.

AU - le Grand, Roger

AU - Scanga, Charles A.

AU - Langermans, Jan A.M.

AU - Bontrop, Ronald E.

AU - Finch, Courtney L.

AU - Flynn, Jo Anne L.

AU - Calcagno, Claudia

AU - Crozier, Ian

AU - Kuhn, Jens H.

PY - 2022/2

Y1 - 2022/2

N2 - Chest X-ray (CXR), computed tomography (CT), and positron emission tomography–computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.

AB - Chest X-ray (CXR), computed tomography (CT), and positron emission tomography–computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.

KW - COVID-19

KW - SARS-CoV-2

KW - imaging

KW - lung

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DO - 10.1016/j.molmed.2021.12.001

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C2 - 34955425

AN - SCOPUS:85121797087

SN - 1471-4914

VL - 28

SP - 123

EP - 142

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 2

ER -

Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

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Keywords

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