TY - JOUR
T1 - Medical history and risk of lymphoma
T2 - Results of a European case-control study (EPILYMPH)
AU - Becker, Nikolaus
AU - Fortuny, Joan
AU - Alvaro, Tomas
AU - Nieters, Alexandra
AU - Maynadié, Marc
AU - Foretova, Lenka
AU - Staines, Anthony
AU - Brennan, Paul
AU - Boffetta, Paolo
AU - Cocco, Pier Luigi
AU - De Sanjose, Silvia
N1 - Funding Information:
Acknowledgments We are indebted to Aurélie Meunier (IARC, Lyon) and Evelin Deeg (German Cancer Research Center, Heidelberg) who performed data management (A.M. and E.D.) and assisted data analysis (E.D.). This work was supported by: the EC 5th Framework Program Quality of Life grant No. QLK4-CT-2000-00422; La Fonda-tion de France, no. 1999 0084 71 (France); the Federal OYce for Radiation Protection grants No. StSch4261 and StSch4420 (Germany); the Health Research Board, Ireland; the Spanish Ministry of Health grants FIS: 04-0091 and CIBERESP (Spain).
PY - 2009/8
Y1 - 2009/8
N2 - Introduction: Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk. Materials and methods: We used the data from the European case-control study Epilymph on 2,362 lymphoma cases and 2,458 controls to investigate associations between a medical history of infectious and non-infectious diseases with overall and subentity-specific lymphoma risk. Results: As key results, we observed an increased odds ratio (OR) for self-reported infections with hepatitis B virus (HBV, OR = 1.91, 95% CL = 1.24-2.94) and a null result for rheumatoid arthritis. Additionally, we found an increased OR for infectious mononucleosis (OR = 1.68, 95% CL = 1.14-2.48), an inverse association to frequency of sickness in childhood (OR = 0.68, 95% CL = 0.55-0.84), and-as casual finding-an increased OR with acetaminophen intake (OR = 2.29, 95% CL = 1.49-3.51). Conclusion: Our results are consistent with the current knowledge about the association with mononucleosis as indicator of Epstein-Barr-virus infection, suggest serological study of the association to HBV infection and do not support the view of a positive association between rheumatoid arthritis and lymphoma risk.
AB - Introduction: Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk. Materials and methods: We used the data from the European case-control study Epilymph on 2,362 lymphoma cases and 2,458 controls to investigate associations between a medical history of infectious and non-infectious diseases with overall and subentity-specific lymphoma risk. Results: As key results, we observed an increased odds ratio (OR) for self-reported infections with hepatitis B virus (HBV, OR = 1.91, 95% CL = 1.24-2.94) and a null result for rheumatoid arthritis. Additionally, we found an increased OR for infectious mononucleosis (OR = 1.68, 95% CL = 1.14-2.48), an inverse association to frequency of sickness in childhood (OR = 0.68, 95% CL = 0.55-0.84), and-as casual finding-an increased OR with acetaminophen intake (OR = 2.29, 95% CL = 1.49-3.51). Conclusion: Our results are consistent with the current knowledge about the association with mononucleosis as indicator of Epstein-Barr-virus infection, suggest serological study of the association to HBV infection and do not support the view of a positive association between rheumatoid arthritis and lymphoma risk.
KW - Acetaminophen
KW - Case-control study
KW - Epidemiology
KW - Epstein-Barr virus
KW - Hepatitis B
KW - Infectious mononucleosis
KW - Rheumatoid arthritis
UR - https://www.scopus.com/pages/publications/68149181738
U2 - 10.1007/s00432-009-0551-2
DO - 10.1007/s00432-009-0551-2
M3 - Article
C2 - 19205736
AN - SCOPUS:68149181738
SN - 0171-5216
VL - 135
SP - 1099
EP - 1107
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
IS - 8
ER -