@inproceedings{f4a9772d035c48c595480b37749132b2,
title = "Medial demons registration localizes the degree of genetic influence over subcortical shape variability: An N= 1480 meta-analysis",
abstract = "We present a multi-cohort shape heritability study, extending the fast spherical demons registration to subcortical shapes via medial modeling. A multi-channel demons registration based on vector spherical harmonics is applied to medial and curvature features, while controlling for metric distortion. We registered and compared seven subcortical structures of 1480 twins and siblings from the Queensland Twin Imaging Study and Human Connectome Project: Thalamus, Caudate, Putamen, Pallidum, Hippocampus, Amygdala, and Nucleus Accumbens. Radial distance and tensor-based morphometry (TBM) features were found to be highly heritable throughout the entire basal ganglia and limbic system. Surface maps reveal subtle variation in heritability across functionally distinct parts of each structure. Medial Demons reveals more significantly heritable regions than two previously described surface registration methods. This approach may help to prioritize features and measures for genome-wide association studies.",
keywords = "heritability, medial curves, meta-analysis, shape registration, spherical demons",
author = "Gutman, {Boris A.} and Neda Jahanshad and Ching, {Christopher R.K.} and Yalin Wang and Kochunov, {Peter V.} and Nichols, {Thomas E.} and Thompson, {Paul M.}",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 ; Conference date: 16-04-2015 Through 19-04-2015",
year = "2015",
month = jul,
day = "21",
doi = "10.1109/ISBI.2015.7164138",
language = "English",
series = "Proceedings - International Symposium on Biomedical Imaging",
publisher = "IEEE Computer Society",
pages = "1402--1406",
booktitle = "2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015",
address = "United States",
}