Mechanobiology of limb musculoskeletal development

Varun Arvind, Alice H. Huang

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


While there has been considerable progress in identifying molecular regulators of musculoskeletal development, the role of physical forces in regulating induction, differentiation, and patterning events is less well understood. Here, we highlight recent findings in this area, focusing primarily on model systems that test the mechanical regulation of skeletal and tendon development in the limb. We also discuss a few of the key signaling pathways and mechanisms that have been implicated in mechanotransduction and highlight current gaps in knowledge and opportunities for further research in the field.

Original languageEnglish
Pages (from-to)18-32
Number of pages15
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - 1 Dec 2017


  • Development
  • Mechanics
  • Mouse
  • Musculoskeletal
  • Tendon


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