Mechanistic connections between mitochondrial biology and regulated cell death

Jerry Edward Chipuk, Jarvier N. Mohammed, Jesse D. Gelles, Yiyang Chen

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The ancient, dynamic, and multifaceted functions of the mitochondrial network are essential for organismal homeostasis and contribute to numerous human diseases. As central hubs for metabolism, ion transport, and multiple macromolecular synthesis pathways, mitochondria establish and control extensive signaling networks to ensure cellular survival. In this review, we explore how these same mitochondrial functions also participate in the control of regulated cell death (RCD). We discuss the complementary essential mitochondrial functions as compartments that participate in the production and presentation of key molecules and platforms that actively enable, initiate, and execute RCD.

Original languageEnglish
Pages (from-to)1221-1233
Number of pages13
JournalDevelopmental Cell
Issue number9
StatePublished - 3 May 2021


  • cell biology
  • mitochondrial function
  • programed cell death
  • regulated cell death
  • signal transduction
  • stress signaling


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