Mechanisms of virus uncoating

Urs F. Greber; Ila Singh; Ari Helenius

doi:10.1016/0966-842X(94)90126-0

Mechanisms of virus uncoating

Urs F. Greber, Ila Singh, Ari Helenius

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.

Original language	English
Pages (from-to)	52-56
Number of pages	5
Journal	Trends in Microbiology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/0966-842X(94)90126-0
State	Published - Feb 1994
Externally published	Yes

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title = "Mechanisms of virus uncoating",

abstract = "In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.",

author = "Greber, \{Urs F.\} and Ila Singh and Ari Helenius",

note = "Funding Information: We thank Paul Webster for providing Fig. 3 and Helena Hoover-Litty and Beate Sodeik for discussions and comments on the manuscript. This work was supported by the National Institutes of Health (A.H.) and by the Cystic Fibrosis Foundation (U.F.G.).",

year = "1994",

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doi = "10.1016/0966-842X(94)90126-0",

language = "English",

volume = "2",

pages = "52--56",

journal = "Trends in Microbiology",

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TY - JOUR

T1 - Mechanisms of virus uncoating

AU - Greber, Urs F.

AU - Singh, Ila

AU - Helenius, Ari

N1 - Funding Information: We thank Paul Webster for providing Fig. 3 and Helena Hoover-Litty and Beate Sodeik for discussions and comments on the manuscript. This work was supported by the National Institutes of Health (A.H.) and by the Cystic Fibrosis Foundation (U.F.G.).

PY - 1994/2

Y1 - 1994/2

N2 - In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.

AB - In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.

UR - https://www.scopus.com/pages/publications/0028009654

U2 - 10.1016/0966-842X(94)90126-0

DO - 10.1016/0966-842X(94)90126-0

M3 - Review article

C2 - 8162442

AN - SCOPUS:0028009654

SN - 0966-842X

VL - 2

SP - 52

EP - 56

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 2

ER -

Mechanisms of virus uncoating

Abstract

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