Mechanisms of stroke in atrial fibrillation

Jose Maria Castellano, Jason Chinitz, Jonathan Willner, Valentin Fuster

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with a high risk of stroke and thromboembolism. Increasing evidence suggests that the thrombogenic tendency inherent to atrial fibrillation is related to several underlying pathophysiological mechanisms, including reduced flow in the left atrium, changes in vessel walls, and changes in blood constituents. This article reviews the mechanisms of stroke, available risk stratification tools and therapies available for prevention of stroke in patients with atrial fibrillation.

Original languageEnglish
Pages (from-to)5-15
Number of pages11
JournalCardiac Electrophysiology Clinics
Issue number1
StatePublished - Mar 2014


  • Atrial fibrillation
  • Cardiac arrhythmia
  • Stroke
  • Thromboembolism


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